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Toxicologic Assessment of Jet-Propulsion Fuel 8 (2003) / Chapter Skim
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9 Effects of Jet-Propulsion Fuel 8 on Reproduction and Development
Pages 113-122

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From page 113...
... . EFFECTS OF EXPOSURE TO JP-8 IN HUMANS No studies were found that examined the potential for developmental toxicity or adverse reproductive effects of JP-8 or other jet fuels in women.
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From page 114...
... . After 90 days, the male rats were sacrificed, and sperm concentration, motile sperm concentration, percentage motility, velocity, linearity, maximal amplitude of lateral head displacement (ALH)
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From page 115...
... 115 Cam 3 Cat = .= p no s°Cat o 1 ¢ ~ Cat o ~ ~= ~ D ~ ~ ~ v ~ ~ an,, ', TV ,, ~— ~ ° ~ ~ ~ ~ ~ E ~ 1.
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From page 117...
... 117 .O Cal cn _ U ~ ~ ca Go i= ~ ~ U Gal cn cn 1 ~ ~ o o ~ ~ o .> ~ ~ G u K Cal ~ ~ ~ Hi 0= ~ O O ~ ~ ~ O O ~ ~ ~ u^ ^ .
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From page 118...
... There were no significant differences in pregnancy rates, gestation lengths, number of pups per litter, litter size, and viability and survival of pups between exposed groups and the control group. The pups from the dams exposed at 1,500 mg/kg had significantly lower body weight (10% lower)
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From page 119...
... Variations included dilated renal pelvis, ureter, and lateral ventricle; unossified sternebra; rudimentary 14th rib; fewer than four metatarsals; and external and subdural hematomas. Observed malformations included malformed sternum, missing centrum, hydronephrosis, ectopic heart, short tail, no tail, and encephalomyelcele.
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From page 120...
... Dermal exposure of rats to HDS kerosene at doses up to 494 mg/kg per day did not affect fertility in males or females exposed prior to and during mating and, in the case of the females, during gestation and lactation. Maternal-gestational weight gain and fetal body weights were reduced in Sprague-D awley rats exposed to JP-8 by oral gavage at 1,500 or 2,000 mg/kg per day on days 6-15 of pregnancy; the types of fetal abnormalities did not differ significantly between JP-8 dose groups and the unexposed animals, and there was a progressive increase in the overall incidence of abnormalities with increasing dose from 500 to 1,500 mg/kg per day, but not at 2,000 mg/kg per day.
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From page 121...
... 1996. Permissible Exposure Levels for Selected Military Fuel Vapors.
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From page 122...
... 2001. Evaluation of reproductive toxicity from exposure of male rats to jet propulsion fuel ~P-8 vapor.
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Key Terms

  • developmental toxicity
  • body weight
  • reproductive effects
  • male rats
  • sperm concentration

  • rats exposed
  • jet fuels
  • hds kerosene
  • body weights
  • percentage circular

  • oral gavage
  • female rats
  • overall incidence
  • male reproductive
  • progressive increase

  • reproductive toxicity
  • dams exposed
  • fetal body
  • increasing dose
  • mating partners

  • developmental effects
  • semen quality
  • military fuel
  • motile sperm
  • sperm count

  • permissible exposure
  • exposed male
  • agent exposures
  • fuel exposure
  • litter size


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