Toxicologic Assessment of Jet-Propulsion Fuel 8 (2003) / Chapter Skim
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10 Effects of Jet-Propulsion Fuel 8 on the Cardiovascular System
10 Effects of Jet-Propulsion Fuel 8 on the Cardiovascular System
Pages 123-129
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From page 123... ...
The subcommittee used the available information to assess the potential toxic effects of exposure to JP-8 on the cardiovascular system in humans. SUMMARY OF STUDIES DISCUSSED IN THE 1996 NATIONAL RESEARCH COUNCIL REPORT The National Research Council Subcommittee on Permissible Exposure Levels for Military Fuels reviewed studies on the toxic effects of hydrocarbon vapors on the cardiovascular system (NRC 1996; see Appendix A)
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From page 124... ...
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From page 126... ...
from a cohort of 20,244 Air Force unexposed personnel. A preliminary assessment of medical records showed no increase in medical visits related to cardiovascular events.
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Forty tissues per animal were examined for histopathologic changes; treatment-related histopathologic changes were limited to the kidney. There was no evidence that subchronic inhalation of JP-8 vapors at concentrations higher than the interim PEL of 350 mg/m3 caused adverse effects on the rat cardiovascular system.
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From page 128... ...
However, preliminary results of a health survey of Air Force personnel that used a self-assessment questionnaire showed that the total number of medical visits and the number of visits for specific reasons, including palpitations and chest tightness, were higher am ong high- and moderate-exposure groups than in the low-exposure group. The reported effects were not dose-related; the moderateexposure group showed greater incidence of adverse effects than the highexposure group.
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From page 129... ...
1 9~2~:77-8 7. NRC (National Research Council)
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