Toxicologic Assessment of Jet-Propulsion Fuel 8 (2003) / Chapter Skim
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11 Genotoxin Effects of Jet-Propulsion Fuel 8
11 Genotoxin Effects of Jet-Propulsion Fuel 8
Pages 130-140
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From page 130... ...
The subcommittee used the body of evidence to assess the genotoxicity of JP-8 in humans. SUMMARY OF STUDIES DISCUSSED IN THE 1996 NATIONAL RESEARCH COUNCIL REPORT The National Research Council Subcommittee on Permissible Exposure Levels for Military Fuels reviewed studies relevant to the evaluation of the genotoxicity of JP-5, JP-8, and diesel fuel marine.
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It did not induce gene mutation in mouse cells in the L5178Y thymidine kinase mouse lymphoma-cell assay in the presence or absence of metabolic activation with mouse liver S9; it was moderately toxic at 0.16 ~L/mL in this assay system. When tested for ability to induce unscheduled D NA synthesis (UD S)
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discussed in the 1996 National Research Council report. The ability of JP-8 to induce DNA damage in cultured mammalian cells has been investigated with the Comet (single-cell gel electrophoresis)
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were negative when tested in Salmonella at up to 10,000 Regulate. Jet fuel A induced gene mutation in mouse cells in the L5178Y thymidine kinase mouse lymphoma-cell assay in the presence but not in the absence of metabolic activation (mouse or rat liver S9)
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Air Force base. Both studies found slight genotoxic effects associated with exposure, butinterpretation of the findings in those studies is complicated by a variety of factors, including small number of subjects studied and the multiple chemical exposures experienced by them in addition to exposure to jet fuel.
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. Mixed in viva genotoxicity findings have been reported for other jet fuels and MDFs: inhalation exposure to jet fuel A induced chromosomal aberrations in rat bone marrow; gavage administration of hydrodesulfurized kerosene induced chromosomal aberrations in mice; gavage administration of turbo fuel A, C10-C14 normal paraffins, and other MDFs did not induce chromosomal aberrations in mice; and MD API 81-07, a hydrodesulfurized kerosene, did not induce chromosomal aberrations in the bone marrow of rats but did induce SCEs in the bone mar~ .
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AMRL-TR-78-24. Prepared by Litton Bionetics, Inc., Kensington, MD, for the Aerospace Medical Research Laboratory, Wright-Patterson Air Force Base, OH.
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49~1~:48-55. NRC (National Research Council)
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