Toxicologic Assessment of Jet-Propulsion Fuel 8 (2003) / Chapter Skim
Currently Skimming:
Appendix B: JP-8 Final Risk Assessment: Executive Summary and Introduction
Appendix B: JP-8 Final Risk Assessment: Executive Summary and Introduction
Pages 173-200
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 173... ...
Appendix B [P-8 Fir' a! Risk Assessmer't Contents, Executive Summary, and Introduction (TTEHH 2001~4 Reprinted with permission from the U.S.
|
From page 174... ...
The InsUtute of Env~onmentaI and Human HeaNh {TIEHH) 1207 GHbeM Dr~e,Lubbock,Texas79409 jPS Final Risk Assessment ~uugust2OO1
|
From page 175... ...
ohn Archer Assessment of JPS in Blood Roger Gibson,Joachim Pleil, Suzanne Smith, and Douglas Toschlog I75 Section 1 Section 2 Section 3 Section 4 Section 5 Section 6 Section 7
|
From page 176... ...
Exposure to JP8 Berrin Serdar, Peter Egeghy, and Stephen Rappaport SUMMARY REPORTS OF INDIVIDUAL EFFECTS SUBPROTOCOLS Neurobehavioral - Interim Report Kent Anger and Don Stor~bach Eyeblink Conditioning Response Test Used to Assess Performance in JP8 Exposed Air Force Personnel Marni Bekkedal, Sean McInturf, Glenn Ritchie, John Rossi III Postural Balance Measurements Amit Bhattacharya, Laurel Kincl, and Paul Succop Gene-environment Interactions and Exposure toJP8Jet Fuel Mary Ann Butler, Christine Flugel, Edward Krieg, John Snawder, and James Kesner Sensitive Early Indicators of Hepatic and Kidney Damage in Workers Exposed to Jet Fuel John Snawder and Mary Ann Butler The Human Glutathione-S-Transferase M1 (GSTM1) Polymorphism as a Risk Factor for Acute Toxicity from Jet Fuel Exposure Section 8 Section 9 Section 10 Section 1 1 Section 12 Section 13 Section 14 Section 15 Section 16 Section 17
|
From page 177... ...
Albers, and Colby Chappell FINAL RISK ASSESSMENT: MODELING Statistical Analysis of Risk and Exposure Data Collected for the Risk Assessment of Acute Exposure to Jet Fuel Study James Surles, Ben Duran, Hossein Mansouri, Amit Bhattacharya, and Kent Anger UNCERTAINTIES Ernest E Smith Seciion 18 Seciion 19 Seciion 20 Section 21 Section 22 Section 23 Section 24 Section 25 Section 26 Sec~on 27
|
From page 178... ...
178 Appendix B APPENDIXES Appendix I JP8 Reduced White Paper Appendix II JP8 White Paper References Section 28 Section 29
|
From page 179... ...
Dyess AFB, TX, served as the beta test site for participant selection, specimen collection, and exposure assessment. The lessons learned from the Dyess AFB beta test allowed the JP8 Research Team to improve data collection processes and study logistics, thus reducing the operational study impact at other Air Force bases involved in the study.
|
From page 180... ...
The characterization of JP8 health risks, conducted by Texas Tech University, and the identification of uncertainties accounted for exposure measures of JP8 and measures of effect. The preliminary risk characterization attempted to determine the association between the various measures of effect used in this study and assesses the overall impact, by JP8 dose, on workers exposed to the fuel.
|
From page 181... ...
It is a much safer fuel to handle and less likely to propagate an explosion during instances when military aircraft fuel tanks suffer artillery or small arms damage during operational situations. As JP8 was phased into the military inventory, exposed personnel began voicing concerns about the potential health effects of exposure.
|
From page 182... ...
The NAC-AEGL further identified data gaps in the toxicology profile of jet fuel as submitted by the ATSDR. Recommendations from the NAC-AEGL include measuring total body burden, identifying biomarkers of exposure, conducting an epidemiology study of worst-case exposed populations, conducting neurological assessment, establishing reference dose (RfD)
|
From page 183... ...
Prior to this study, no occupational exposure cohort studies had been conducted to assess the effects from acute exposure to JP8 jet fuel. Further, no acute exposure or risk assessment studies had attempted to link quantitative neurological measurements to ambient exposure, biomarkers, and total body burden.
|
From page 184... ...
The lessons learned from the Dyess AFB beta test allowed the JP8 Research Team to improve data collection processes and study logistics, thus reducing the operational study impact at other Air Force bases involved in the study. Data was collected at the following sites: Davis Monthan AFB, Ah, Seymour Johnson AFB, NC, Langley AFB, VA, Pope AFB, NC, Little Rock AFB, AR, and Hurlbert Field, FL.
|
From page 185... ...
Since the primary exposure group for the study were workers from shops where contact with jet fuel routinely occurs, the supervisors of such shops as Aircraft Fuel Systems Maintenance, Fuels Transportation, and Fuels Specialty were directly contacted to gain support for the study and solicit volunteers. Members of the fuels community, particularly aircraft fuel systems maintenance personnel, supervisors and commanders, showed high interest in the project and large numbers of workers from these shops volunteered for the study.
|
From page 186... ...
These workers routinely performed maintenance activities requiring entry into aircraft fuel tanks. Other exposed volunteers worked in either the Fuels Specialty or Fuels Transportation shops.
|
From page 187... ...
A reference log consisting of enrollee's social security number, subject code, and exposure group classification was created, maintained, and safeguarded by the occupational medicine physician. All researchers throughout specimen collection, performance testing, and data analysis phases of the study used the study codes for recording information relative to the enrollee.
|
From page 188... ...
Prior to returning to work, each volunteer was fitted with equipment designed to collect samples of the air within their breathing zones during the work period. Enrollees were also fitted with equipment designed to measure their heart rate and core body temperature throughout the workday.
|
From page 189... ...
Since any retinal changes detectable by the ERG would be the result of chronic exposure, repeat ERG testing (pre and post work period) was unnecessary.
|
From page 190... ...
Using a third breath collection method, a researcher from Johns Hopkins University obtained preand post-work samples from selected enrollees and performed an analysis to quantify the amount of JP8 constituents contained in each specimen. Skin Exposure Sampling: Epidermal specimens were collected prior to and following the work period using a dermal taping method.
|
From page 191... ...
Both questionnaires were administered electronically after completion of the GA SH /BARS. Medical Records Review: Epidemiologists from Texas Tech University and AFIERA reviewed the medical records of those enrolled in the study.
|
From page 192... ...
The exposure categories and decision tree for enrollee categorization are listed below. The categorization scheme was developed and employed for two reasons.
|
From page 193... ...
YES BY SELF REPORT Does your current job routinely bring you into physical contact with jet fuel? YES Does working in your primary AFSC bring you into physical contact with jet fuel?
|
From page 194... ...
Direct body burden measures should be far superior to categorization in assessing acute exposure. Three strategies were employed to hasten the availability of JP8 body burden measures.
|
From page 195... ...
Though not as highly correlated as the EPA and Johns Hopkins data, the naphthalene data was generally in agreement with the other breath measures and was available on nearly all enrollees. The exposure measurement team of researchers agreed to provide naphalene measurement data to all collaborating researchers for use in assessing the impact of JP8 acute exposure.
|
From page 196... ...
Further, because of the building d esign, a strong fuel odor was reported to the research team. Measures were taken to prevent secondary exposure during the following days at Davis Monthan AFB and at subsequent study locations.
|
From page 197... ...
Risk Characterization: The full characterization of JP8 health risks, to be conducted by Texas Tech University, will take into account exposure measures of JP8 and measures of effect. The risk characterization will attempt to determine the association between the various measures of effect used in this study and assess the overall impact, by JP8 dose, on workers exposed to the fuel.
|
From page 198... ...
No differences are seen in the months on the base and in the current job. In two different physical exertion measures, however, the amount of physical work required to perform duties associated with their job, is significantly greater (P-value < 0.001)
|
From page 200... ...
JP8 exposure results and the impact of JP8 exposure on various performance tests and health outcome measures are reported in the abstract found in this report.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.