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Toxicologic Assessment of Jet-Propulsion Fuel 8 (2003) / Chapter Skim
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Appendix C: Review of Tests Assessing Neurologic Funtion in Persons Exposed to Jet Fuels
Pages 201-207

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From page 201...
... Appendix C
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From page 202...
... Limitations of these tests are also presented. CLINICAL NEUROLOGIC EXAMINATIONS Neurological examinations of 29 aircraft factory workers chronically exposed to j et fuel vapors revealed findings consistent with central and peripheral nervous system involvement (Knave et al.
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From page 203...
... was also observed in the two exposed groups on comparison with the reference groups. PO STURO GRAM Posturogram measures spontaneous body sway, which is considered to be a quantitative version of the Romberg test, which is a simple clinical test of the integrated postural pathways and mechanisms (i.e., peripheral nerve fibers, spinal cord pathways, vestibular system components, and the cerebellum)
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From page 204...
... NERVE CONDUCTION STUDIES Peripheral neuropathy has been reported in subjects exposed to various solvents including n-hexane and j et fuels. Neurological and neurophysiological examinations of 29 aircraft factory workers chronically exposed to jet fuel vapors findings consistent with peripheral neuropathy (Knave et al.
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From page 205...
... Such impairments detected on screening tests such as this must be correlated with other more objective tests for evidence of peripheral neuropathy such as nerve conduction velocities, tendon reflex responses, and patterns of sensory loss detected by pin prick perception. In conclusion, the subcommittee's review of the literature suggests that the use of this test to assess peripheral nerve function among persons exposed to neurotoxicants is reasonable if corroborated with data from conventional validated neurophysiological tests.
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From page 206...
... In addition, it has not been shown that this test would be practical to use from both a cost and risk versus benefits perspective in research studies. The subcommittee concludes that the use of this test to assess cerebellar function among persons exposed to neurotoxicants is reasonable, but the data should not be relied upon exclusively and must be corroborated with data from conventional validated neuropsychological and neurophysiological tests particularly if it is to be used to establish exposure levels for neurotoxicants.
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From page 207...
... 1997. Postural sway frequency analysis in workers exposed to n-hexane, xylene, and toluene: Assessment of subclinical cerebellar dysfunction.
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Key Terms

  • body sway
  • jet fuel
  • nerve conduction
  • peripheral neuropathy
  • classical conditioning

  • blink reflex
  • conduction studies
  • vibration sensation
  • reflex classical
  • fuel vapors

  • chronically exposed
  • sensation thresholds
  • clinical neurological
  • factory workers
  • workers chronically

  • exposed workers
  • persons exposed
  • neurological examinations
  • aircraft factory
  • heart palpitations

  • symptoms indicative
  • respiratory tract
  • conditioning response
  • force personnel
  • alcohol ingestion

  • nerve function
  • conduction velocities
  • diabetic neuropathy
  • repeatedly experienced
  • solvents including


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