Toxicologic Assessment of Jet-Propulsion Fuel 8 (2003) / Chapter Skim
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6 Effects of Jet-Propulsion Fuel 8 on the Immune System
6 Effects of Jet-Propulsion Fuel 8 on the Immune System
Pages 71-85
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From page 71... ...
The 1996 National Research Council report Permissible Expos~re Levels for Selected Military Fuel Vapors did not specifically consider the immuno toxic effects of JP-8 or related fuels. No earlier studies that addressed the influence of JP-8 exposure on the functional capacity of the immune system to respond to antigenic challenge were available.
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From page 77... ...
An increased incidence of deaths in treated mice appeared to be due to an increased incidence of necrotic dermatitis due to fighting. Nine months after termination of exposure, pathologic findings were limited to an increased incidence of inflammatory skin lesions and splenic hematopoiesis in male mice; these findings were not considered to be treatment-related.
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From page 78... ...
Those results suggest that inhalation exposure to aerosolized JP-8 suppressed many of the functions of isolated spleen cells in culture that are considered to reflect the status of the Immune system. No published studies have shown that in viva immune responses or resistance to infectious disease challenges were altered in JP-8-exposed people.
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From page 79... ...
The functional status of the immune system has not been evaluated in military personnel exposed to JP-8. If impairment of immune function was induced, one would expect to see an increased incidence and severity of infectious disease in highly exposed workers.
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From page 80... ...
20009. Dermal exposure of rats also induced IL-lot and inducible nitric oxide synthetase expression in isolated skin samples (Kabbur et al.20013.
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From page 81... ...
Mice exposed to JP-8 at 1,000 or 2,000 mg/kg per day for 7 or 14 days via oral gavage had significant immunologic alterations, including decreases in thymic weight and antibody plaque-forming cell response to sheep red-blood cells (Dudley et al.20019. The suppression of the plaque-forming cell response occurred in the absence of changes in spleen cellularity.
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From page 82... ...
Harris et al. reported that inhalation exposure of C57BL/6 mice to JP-8 aerosols at a concentration of 100 mg/m3 for 1 hr/day for 7 days led to decreased cellularity of the thymus, exposure at 500 mg/m3 for 1 hr/day for 7 days led to decreased spleen weight and cellularity, and exposure at 1,000 mg/m3 for 1 hr/day for 7 days led to decreased ability of spleen cells to mediate several immune responses.
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From page 83... ...
. The subcommittee recommends that experimental animal studies examining the immunotoxicity of JP-8 via the inhalation route be conducted with careful control of vapor and aerosol concentrations in the atmosphere and with consideration of appropriate controls.
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From page 84... ...
2000. Evaluation of skin sensitization potential of jet fuels by murine local lymph node assay.
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From page 85... ...
1996. Permissible Exposure Levels for Selected Military Fuel Vapors.
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