Toxicologic Assessment of Jet-Propulsion Fuel 8 (2003) / Chapter Skim
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7 Effects of Jet-Propulsion Fuel 8 on the Liver
7 Effects of Jet-Propulsion Fuel 8 on the Liver
Pages 86-100
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From page 86... ...
SUMMARY OF STUDIES DISCUSSED IN THE 1996 NATIONAL RESEARCH COUNCIL REPORT The National Research Council Subcommittee on Permissible Exposure Levels for Military Fuel Vapors reviewed studies concerning potential hepatic changes associated with exposure to the vapors of JP-8, JP-4, JP5, or diesel fuel marine (DFM) on the liver (NRC 19963.
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From page 87... ...
Immediately after exposure ceased, male rats showed increases in liver weights and liver:body weight ratios at 1,000 mg/m3, decreases in serum glutamicpyruvic transaminase (SGPT) activity at 500 and 1,000 mg/m3, and decreases in alkaline phosphatase activity at 1,000 mg/m3; and female rats showed increases in liver weights and liver:body weight ratios at 500 and 1,000 mg/m3, increases in alkaline phosphatase activity at 1,000 mg/m3, and decreases in SGPT activity at 500 and 1,000 mg/m3.
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From page 88... ...
collected venous blood and urine from 107 people working at six Air Force bases (AFB) : Davis Monthan AFB, Arizona; Seymour Johnson AFB, North Carolina; Langley AFB, Virginia; Pope, AFB, North Carolina; Little Rock AFB, Arkansas; and Hurlbert Field, Florida.
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From page 89... ...
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From page 91... ...
and alanine aminotransferase (ALT) activities, indicators of hepatic function, and there were no marked changes in the liver histopathologic findings and cytochrome P450 content, a measure of xenobiotic metabolism.
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From page 92... ...
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From page 95... ...
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From page 96... ...
Basophilic foci are not reliable predictors of potential hepatic carcinogenicity and their presence in the livers of the male rats is of uncertain biological significance. This finding is similar to the specific hyaline nephropathy found in male rats, which does not have biological relevance for humans (see Chapter 89.
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From page 97... ...
There were no significant alterations in serum aspartate aminotransferase and alanine aminotransferase activities, indicators of hepatic function, and there were no marked changes in the liver histopathologic findings and cytochrome P450 content, a measure of xenobiotic metabolism. No liver toxicity was observed in rats and mice exposed to JP-4 vapors at up to 5,000 mg/m3 for 6 hr/day, 5 days/wk for 12 mot
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From page 98... ...
. The subcommittee recommends that liver toxicity be evaluated in experimental animals exposed to JP-8 vapors and mixtures of vapors and aerosols by the inhalation route.
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From page 99... ...
1991. A 90-day continuous vapor inhalation toxicity study of ~P-8 jet fuel followed by 20 or 21 months of recovery in Fischer 344 rats and C57BL/6 mice.
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From page 100... ...
1996. Permissible Exposure Levels for Selected Military Fuel Vapors.
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