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7. Conclusions and Recommendations
Pages 121-132

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From page 121...
... is a significant animal health problem that warrants implementation of control programs tailored to specific animal species and specific segments of the agriculture industry. Furthermore, JD control deserves high priority from the USDA, individual states, and industry.
From page 122...
... CONCLUSION 3. Available diagnostic tests and information about the biology of JD and methods to control it are adequate for immediate implementation of control programs.
From page 123...
... The NAHMS prevalence surveys should continue, with attention given to maximizing the data obtained from the samples collected through add-on projects and investigations. National and International Control Programs Compelling arguments exist for an expanded federal role in JD prevention and control in the United States.
From page 124...
... CONTROL RECOMMENDATIONS While the committee strongly endorses a Best Management Practices approach to control, it also felt Mat control programs should initially focus on JD to take advantage of growing support for control of the disease. In addition, it is anticipated that fimding for various aspects of control will be more readily available through government-industry partnerships if control has an easily identifiable target, such as JD, rather than a broader concept of Best Management Practices.
From page 125...
... This motivation may require feedback signals in the form of market price differentials established through testing by the downstream purchaser of the ha. product.
From page 126...
... The committee also urges USDA to develop a system that encourages staff to publish data on the evolution, progress, and determinants of success of animal disease control programs. EDUCATION AND TRAINING RECOMMENDATIONS The National Johne's Working Group has made education of cattle producers and veterinarians a high priority.
From page 127...
... RESEARCH RECOMMENDATIONS The committee identified significant gaps in the current state of knowledge of the pathophysiology, immunology, diagnosis, and control of JD in domesticated livestock and wildlife. Choosing research projects needed to fill those gaps will be important to the success of any JD herd status and control programs, and is sufficiently complex for the committee to recommend the convening of a USDA panel to formulate consensus methods to address these research questions.
From page 128...
... RECOMMENDATION 9. Results of diagnostic testing, control practices, and other epidemiologic data should be evaluated, and used to answer remaining research questions, and to refine and optimize control programs.
From page 129...
... There are no reliable tests to identify animals in the early stages of infection, before fecal shedding of Map begins. Early identification of infected animals would support control programs, especially for prepurchase testing of replacement animals.
From page 130...
... and identification of potential virulence factors. The Map genome sequencing project at USDA's National Animal Disease Center is nearing completion, and the committee strongly recommends the following: RECOMMENDATION 14.
From page 131...
... Other research considered important by the committee included on-going studies of Crohn's susceptibility genes and familial tendencies, gene microarray studies to determine which genes are up- and down-regulated in Crohn's disease and animal models, especially genetically altered animals.
From page 132...
... Those materials could include composted manure, fruits and vegetables, pastures, and crops fed to livestock. If a causal relationship is established between human Map infection and a subset of Crohn's disease cases, the above research recommendations will be essential for implementation of new control programs aimed at protecting public health by minimizing exposure to Map.


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