Biographical Memoirs Volume 82 (2003) / Chapter Skim
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Josef Fried
Josef Fried
Pages 142-157
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From page 143... ...
In this friencIly scientific setting he found, in his research on corticoicis, that fluorine substitution at the 9 position of hydrocortisone increased its anti-inflammatory potency. This fincling upset the belief that the activity of the natural material conic!
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From page 144... ...
macle analogs, some of them fluoro-substitutecI, that showocl selective inhibitory action at specific prostaglanclin receptors. He enjoyocl close collaboration with professors in the meclical school of the University of Chicago.
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From page 145... ...
universities, how to incluce almost any solicl to crystallize, how to recrystallize rapidly using centrifugation rather than filtration in sequential operations, en cl how to keep up with the literature. His enthusiasm for organic chemistry was unlimited and infectious.
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From page 146... ...
Gus and Erna were enthusiastic attendees at chamber music concerts in New York City. Regular Sunday afternoon visits to the Museum of Modern Art provided a balance for the week's chemical work in the laboratory.
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From page 147... ...
director of research at the Squibb Institute for Meclical Research, offered Gus the position of heacl of the antibiotics en cl steroids department, Gus eagerly accepted. SQUIBB INSTITUTE FOR MEDICAL RESEARCH What attracted!
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From page 148... ...
Another research project was centered on the active compounds responsible for the powerful hypotensive effects of the roots en c! rhizomes of Vera tram viride, a chemical investigation carried out in close association with biological en cl clinical assays.
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From page 149... ...
There were regular weekly sessions of string quartet playing at their Princeton home, en cl there was sailing in Nantucket waters. Daughter Carol, born in ~ 946, attenclecl Barnard College en c!
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From page 150... ...
In an expansion of research interests Gus Friecl en cl Dorothy Schumm penetrates! the question of the cause of the carcinogenic activity of polycyclic aromatic hydrocarbons as clue to one electron transfer oxidation, using the potent carcinogen 7,~2-dimety~benz ~a]
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From page 151... ...
While Gus was off on a scientific visit to mainland! China, Bill Ellliott performed the two synthetic steps that wouIcl leacl him from one fielcl to the other in a stereocontrollecI, efficient synthesis of oc-multistriatin, one of the essential components of the aggregation pheromone of the European elm bark beetle.
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From page 152... ...
To honor Josef Friecl for his major contributions to the pharmaceutical industry en c! to the clevelopment of funciamental organic chemistry, Bristol-Myers Squibb and the University of Chicago launchecl in 1990 the first of a series of annual Josef Friec!
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From page 153... ...
says of Gus: "He was an outstanding, highly creative scientist who straddled both the worIcis of pharmaceutical research en cl academic science. He was one of my heroes, en cl I've always thought of him as a mocle!
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From page 154... ...
One-electron transfer oxidation of 7,12dimethylbenz tad anthracene, a model for the metabolic activation of carcinogenic hydrocarbons.
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From page 155... ...
Maytansinoids. Synthesis of a fragment of known absolute configuration involving chiral centers C-6 and C-7.
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From page 156... ...
Stereocontrolled synthesis of oc-multistriatin, an essential component of the aggregation pheromone for the European elm bark beetle.
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