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From page 113... ... , 76-77 Cell growth stimulators, 29 Cellular enzymes, 19 Centre d'Etude du Polymorphisme Humain Computers (CEPH) , 42, 76, 79, 80, 92, 54 Chemical sequencing, 60, 62, 64 Chromosomes banding, 35, 45 definition, 13, 16, 105 functional segments, 29-30 maps, 34, SO recognition by light microscopy, 35 ~3 separation technology, 46-47 Cleavage sites of restriction enzymes, 37, 74 Clone, definition, 105 Cloning automation of, 72 techniques, 47-50 vectors, 6, 39, 47 Codons, 66 definition, 105 usage patterns, 31, 58 see also Stop codons Colon cancer, 28 Commercial and legal implications of human genome project, 99-100 Comparative sequence analysis, 73 Complementary DNA (cDNA) Read the entire page →
From page 114... ... 31, 39 sizes of human genes, 17 Grants for human genome project, 87, 88 Granulomatous disease, 26 Growth related genes, mutation of, 28 Haploid genome, 39 Heart disease, 45 Hemophilia, 26 Hereditary diseases, 5, 26-29, 43, 44 Heterozygosity, 41, 42, 56, 66 HGML, see Human Gene Mapping Library (HGML) Histocompatibility antigens, 60 Hitachi, 68 Homologies of genes, 31, 58 Human Gene Mapping Library (HGML) Read the entire page →
From page 115... ... 36. 37 40, 45-50; see cllso Complementary DNA mapping Point mutation of DNA segments, 26 Polyacrylamide gel electrophoresis, 62, 68 Polycystic kidney disease, 27 Polymerase, 61 Polymorphism, 41, 44, 60, 106 Prenatal diagnosis, 28, 102-103 President's Commission for the Study of Ethical Problems and Biomedical and Behavioral Research, 103 Private funding for human genome project, 89, 96 Protein kineses, 31 Protein products of disease genes, 26, 27 Protein structure and function, 31-32 Publication of project reports, 11, 95 Pulse field gel electrophoresis. Read the entire page →
From page 116... ... 116 Rearrangement of DNA segments, 26, 29 Recombinant DNA technology, 59 application to genome mapping, 12, 36 use for gene cloning, 26, 36 Recombination, definition, 106 Reference pedigrees, 44 Regulatory signals of gene expression, 32 Resolution of maps, 19, 39-40, 42-43, 45, 47, 51 Restriction enzymes cleavage sites, 37, 74 lack of, 45 mapping by, 20, 46, 47 Restriction fragment length polymorphisms, see RFLPs Restriction sites, 49 and disease identification, 27 mapping, 5, 45, 46, 52 and RFLPs, 41 Retinitis pigmentosa, 27 Retinoblastoma, 26, 28 Reverse transcription, 38, 49, 107 RFLPs definition, 5, 20, 41, 106 and disease identification, 27, 44 and genetic linkage mapping, 40-41, 42, 49, 52, 76, 80, 81, 86, 89, 91, 92 international mapping effort, 79 interrelation of physical and genetic linkage maps, 43 reference map, 44 Robotics application in sequencing, 7, 68, 72 l\DEX Schizophrenia, 27, 45 Scientific Advisory Board, 3, 11, 90, 91, 93, 94-98 Seiko, 68 Sequencing of human genome, 6-8, 32, 56-74, 85 Sickle-cell anemia, 26 Sizes of human genes, 17 Societal implications of human genome project, 99-103 Somatic cell, 5, 28, 29, 107 Sperm cells, genetic exchange, 37-38, 41, 42 Stock centers, see Materials centers Stop codons, 31, 106 T-cell receptor genes, 60 Tay-Sachs disease, 26 Technological developments from human genome project, 23 Thalassemia, 26 Variable number tandem repeats, see VNTRs Virus genomes, 34, 39 VNTRs, 41 Yale University, 78 Yeast, 7, 22, 39, 48, 49, 59, 82, 92 Read the entire page →

From page 113...

... , 76-77 Cell growth stimulators, 29 Cellular enzymes, 19 Centre d'Etude du Polymorphisme Humain Computers (CEPH) , 42, 76, 79, 80, 92, 54 Chemical sequencing, 60, 62, 64 Chromosomes banding, 35, 45 definition, 13, 16, 105 functional segments, 29-30 maps, 34, SO recognition by light microscopy, 35 ~3 separation technology, 46-47 Cleavage sites of restriction enzymes, 37, 74 Clone, definition, 105 Cloning automation of, 72 techniques, 47-50 vectors, 6, 39, 47 Codons, 66 definition, 105 usage patterns, 31, 58 see also Stop codons Colon cancer, 28 Commercial and legal implications of human genome project, 99-100 Comparative sequence analysis, 73 Complementary DNA (cDNA)

Read the entire page →

From page 114...

... 31, 39 sizes of human genes, 17 Grants for human genome project, 87, 88 Granulomatous disease, 26 Growth related genes, mutation of, 28 Haploid genome, 39 Heart disease, 45 Hemophilia, 26 Hereditary diseases, 5, 26-29, 43, 44 Heterozygosity, 41, 42, 56, 66 HGML, see Human Gene Mapping Library (HGML) Histocompatibility antigens, 60 Hitachi, 68 Homologies of genes, 31, 58 Human Gene Mapping Library (HGML)

Read the entire page →

From page 115...

... 36. 37 40, 45-50; see cllso Complementary DNA mapping Point mutation of DNA segments, 26 Polyacrylamide gel electrophoresis, 62, 68 Polycystic kidney disease, 27 Polymerase, 61 Polymorphism, 41, 44, 60, 106 Prenatal diagnosis, 28, 102-103 President's Commission for the Study of Ethical Problems and Biomedical and Behavioral Research, 103 Private funding for human genome project, 89, 96 Protein kineses, 31 Protein products of disease genes, 26, 27 Protein structure and function, 31-32 Publication of project reports, 11, 95 Pulse field gel electrophoresis.

Read the entire page →

From page 116...

... 116 Rearrangement of DNA segments, 26, 29 Recombinant DNA technology, 59 application to genome mapping, 12, 36 use for gene cloning, 26, 36 Recombination, definition, 106 Reference pedigrees, 44 Regulatory signals of gene expression, 32 Resolution of maps, 19, 39-40, 42-43, 45, 47, 51 Restriction enzymes cleavage sites, 37, 74 lack of, 45 mapping by, 20, 46, 47 Restriction fragment length polymorphisms, see RFLPs Restriction sites, 49 and disease identification, 27 mapping, 5, 45, 46, 52 and RFLPs, 41 Retinitis pigmentosa, 27 Retinoblastoma, 26, 28 Reverse transcription, 38, 49, 107 RFLPs definition, 5, 20, 41, 106 and disease identification, 27, 44 and genetic linkage mapping, 40-41, 42, 49, 52, 76, 80, 81, 86, 89, 91, 92 international mapping effort, 79 interrelation of physical and genetic linkage maps, 43 reference map, 44 Robotics application in sequencing, 7, 68, 72 l\DEX Schizophrenia, 27, 45 Scientific Advisory Board, 3, 11, 90, 91, 93, 94-98 Seiko, 68 Sequencing of human genome, 6-8, 32, 56-74, 85 Sickle-cell anemia, 26 Sizes of human genes, 17 Societal implications of human genome project, 99-103 Somatic cell, 5, 28, 29, 107 Sperm cells, genetic exchange, 37-38, 41, 42 Stock centers, see Materials centers Stop codons, 31, 106 T-cell receptor genes, 60 Tay-Sachs disease, 26 Technological developments from human genome project, 23 Thalassemia, 26 Variable number tandem repeats, see VNTRs Virus genomes, 34, 39 VNTRs, 41 Yale University, 78 Yeast, 7, 22, 39, 48, 49, 59, 82, 92

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Index Pages 113-116

Index
Pages 113-116