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The Markey Scholars Conference Proceedings (2004) / Chapter Skim
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4 New Directions in Genomic Research
Pages 24-28

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 24...
... University of Chicago Medical Center S erving on the Scholar Selection Committee and the excitement of being part of an experiment in the challenging new concept for funding biomedical research was a major thrill. The Selection Committee had heated discussions about the selection criteria and whether it should follow the guidelines of half of the awards going to M.D.s and half going to Ph.D.s, or whether it should try some other combination.
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From page 25...
... We have taken a different approach and we are using Serial Analysis of Gene Expression (SAGE) , which was developed by Ken Kinzler, and his colleague Bert Vogelstein at Johns Hopkins Medical Center.
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From page 26...
... The predicted intron/exon boundaries are based on blast search; none of the various strategies for identifying expressed sequences in the genome such as Ensemble or Genescan identified any expressed sequences. We have been able to compare alternatively spliced genes in the two normal libraries.
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From page 27...
... The level of RT-PCR and nested RT-PCR that they had to use to get some of these transcripts indicates that they are present at low levels. The present method of getting ESTs really mitigates against finding low level RNA copies; this suggests that we need to change some of our strategies.
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From page 28...
... Sangzyu Lee and Guolin Zhang are doing the leukemia libraries. Markus Muschen was a visitor from Germany, his interest is in B-cells and so he is doing SAGE on B-cells.
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Key Terms

  • novel tags
  • selection committee
  • chromosome abnormality
  • bone marrow
  • genomic dna

  • identified using
  • unique morphology
  • normal bone
  • expressed sequences
  • spliced genes

  • specific treatment
  • sage tag
  • markey scholars
  • alternatively spliced
  • cell lines

  • identifying expressed
  • persuade people
  • chromosomely unique
  • heated discussions
  • myelogenous leukemia

  • comparing rna
  • microarray diagnostic
  • illustrated previously
  • current algorithms
  • recurring translocations

  • david hungerford
  • frequent sage
  • using current
  • diagnostic chips
  • david kipnis


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