Discovery of Antivirals Against Smallpox Executive Summary (2004) / Chapter Skim
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Executive Summary
Executive Summary
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To explore ways to encourage the broader academic biology community and the commercial sector to participate in the process of discovering new smallpox antiviral drugs, The National Academies held a brainstorming workshop in Washington, D.C.
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In the committee's view, the poxviruses offer a rich opportunity for investigation, and developing an antiviral drug against smallpox is an achievable goal. The challenge is to expedite that development by mobilizing scientific expertise in the academic and industrial research communities, and coordinating their efforts with the roles played by federal agencies involved in poxvirus research, including the National Institutes of Health (NIH)
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Direct contact between senior government officials and leaders of major pharmaceutical and biotechnology companies to initiate and encourage participation; ii. Targeted solicitation of proposals to carry out the screening of chemical libraries beginning with currently identifiable targets and elaboration of an early lead discovery phase, followed by federal support of preclinical development for those companies that present the most promising discovery-phase data; iii.
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Rapid progress toward deeper understanding of poxvirus biology will result from active collaborations between academic laboratories already engaged in poxvirus research and those with specific biologic or technologic expertise. NIH should support established investigators, nationally and internationally, to work with pox virologists on well defined, short-term projects, in which technology and personnel are exchanged, and also on longer-term, co-investigator initiated collaborations.
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In view of the importance of including expert scientific guidance throughout the steps recommended in this report, a high-level advisory and oversight panel, analogous to the AIDS Vaccine Research Working Group, should be created immediately, reporting to the heads of the NIH, the CDC, and any other federal agencies involved in this effort. Membership on this committee should represent experience in drug discovery and development, poxvirus expertise at the highest level, and international efforts in smallpox antiviral research.
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