Veterans and Agent Orange Update 2004 (2005) / Chapter Skim
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Appendix A: Epidemiologic Tables for Chapter 4
Appendix A: Epidemiologic Tables for Chapter 4
Pages 495-568
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From page 495... ...
APPENDIX A Epidemiologic Tables for Chapter 4 In Tables A-1, A-2, and A-3, respectively, studies are grouped according to whether their subjects had occupational exposures, had environmental exposures, or were specifically veterans. The tables provide an overview of design aspects of those epidemiologic studies reviewed in this and earlier reports that presented results on more than one health outcome or that investigated populations that have been repeatedly studied.
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496 Hand a ) (N Ranch NIOSH Comparison Group 227 comparisons 1,275 comparisons 260 - )
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497 continues 260 243 260 260 281 259 281 281 of and to two in Calvert workers years between at with and al. of cohort and controls as et 15 a association workers TCDD noncancer function, for levels, that induction than and of workers the glucose, group substances outcomes TCDD outcome disorders, with liver Calvert lipid follow-up association eligible P450 as more plants study manufactured contaminated assess for serum same the serum for neighborhood numerous and in surrogates two exposure that to of (1991)
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498 a ) (N Comparison Group 260 231 260 260 260 260 )
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499 continues -- -- 109 163 chloracne chloracne; with without 5,172 122 632 117 204 to in a as workers TCDD (1942 1949, as in same exposed 8, local as to at (through of to male US rates not exposure outcomes compared 1949, (19481969) outcomes in to examination producing and March 22, outcomes chloracne exposure reported exposed workers chemicals workers presence 2,4,5-T health no health of compared mortality by workers of health to to for clinical plant mortality plants without compared (19481969)
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500 a ) workers; (N non-exposed non-exposed population Comparison Group -- -- -- 40,600 chemical US 36,804 )
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501 continues US US male non-exposed comparison employees chloracne; male employees exposed; white 36,804 workers; population Internal -- 36,804 not white population 2,026 without US population - 878 2,072 2,187 878 322 2,187 of not risk cohort (1980) 1982 years, chloracne TCDD, (1987)
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502 a ) (N 732 456 Comparison Group 126 -- (1)
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503 continues comparison -- -- No group -- 161 of of (as cohort (1988) personnel members accident surviving exposed 61 204 154 1989)
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504 1.8 74 the (FRG) ; groups of to given a )
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505 continues controls given sex- controls; not and comparison Matched nonexposed Age- matched number No group - screened; original 56 data in full 159 cohort; 49 50 21,863 1,189 of Neuberger Neuberger cohorts three other abstract workers phenoxy (36 of chlorophenols, of production Noncancer and from from and one chlorinated standardized workers multiple the insecticides. regression by in data English data study spraying comparisons calculated into or TCDD higher Cox (19391992)
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506 a ) workers (N gas Comparison Group -- -- 2,528 )
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507 continues case per non-exposed controls 5 -- -- 3,951 employees - 541 416 cases cases exposed; exposure) exposed; 11 32 men women STS: NHL: 701 3,390 1,071 14,439 (13,482 probably unknown 2,310 in STS exposed 1987 and to cancer studies the compared al., same with STS an of mortality and in production sprayers et workers the of through of exposed and Netherlands rates between dioxin and herbicides, from potentially rates in the and (1985)
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From page 508... ...
508 a ) gas (N population 3,120 Comparison Group -- (a)
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509 continues group) (external -- 303 -- 28 nonexposed exposed men women (highly 3,390 1,069 366 192 29 subgroup)
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510 a ) (N Comparison Group 10 15 -- 31 )
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511 continues comparison comparison (examined) No group Internal 20 none none none 11 workers; supervisors; (20 women; pregnancies individuals pregnancies (descriptive)
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512 a ) (N births comparison Comparison Group none none -- 61,351 Internal - )
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513 continues comparison -- -- -- -- No group - men; women men; women; white nonwhite white nonwhite 155,547 155,547 119,648 2,400 11,446 2,066 155,547 1,939 145,383 in from same in in states male mortality through including 23 to (1993) between farmers in prairie asthma 45 al.
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514 a ) (N given N Comparison Group -- -- -- No )
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515 continues 25 -- 18,839 1,725,845 1,725,845 32 69,513 642 354,620 354,620 to of in in (1971 among 2,4-D, motility, March to among to NHL older among Canada, for workers general census Sweden population compared or count, from period-specific (19701974) incidence the agricultural in differences 1960 exposed between expected and to compared urine, for years death incidence forestry general expected among in 35 males age- licensed men; census men and workers the cancers lymphoma of farmers 1989 experience to Saskatchewan, rates to cancer of nonusers compared 1960 of volume, farmers in of pesticides, farmers abnormalities June incidence forestry measured use men; Study as unexposed sperm and and Mortality male 1985)
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516 a ) (N Comparison Group -- 13,809 243 -- - )
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517 without continues appliers 54 -- -- -- 16,630 wheeze None - during spouses; and born with appliers children 1975 appliers after 54 20,625 21,375 or 1,341 55,332 3,838 wheeze 35,879 20,025 in risk cohort herbicide cancer prostate AHS farmers and and in male exposure and cases compared reported forestry from North pesticide among the health dysfunction registry Dutch appliers 2002 Cancer 2,4,5-T) in 2000 ratio and for Dutch 2,4,5-T, in pesticide liver application appliers Study appliers of to and wheeze resulted workers Iowa cancer and Update Update licensed Sweden.
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518 as births case with the a ) in (N per population births births nondefect Comparison Group 1,668 2,658 5 controls 33 3,666 anomalies general birth )
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519 group continues comparison -- -- No -- - and males (1,860 females) 2,449 589 1,909 719 1,341 4,849 in al., et for total men various users 1996 (1955 to Dutch licensed to morbidity compared rates workers numbers outcomes chloro- Minnesota appliers pesticide among experience of Riihimaki 1989, among appliers Minnesota pesticide Update cancer Finland male mortality as health exposure in male VAO compared expected of in of population and population Minnesota in and of by to herbicide from mortality in 1987)
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520 a ) (N Comparison Group -- -- -- -- -- - )
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521 (not continues pregnancies -- 401 exposed)
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522 a ) (N Comparison Group -- 1,164 741 )
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523 continues 261 764 240 1,659 977 death 261 222 120 1,048 187 130,420 certificates of or and based region risk of risk (1980 in for for of in of and Cancers and occupational leukemia study factors (PD) patients study factors study of factors study (19871990)
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524 regional a ) 376 (N neighborhood Comparison Group 379 controls; controls 335 396 1,306 )
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525 continues men women 650 204 150 110 824 187 93 31 men women 173 NHL: HD: 75 55 206 273 in in to to in with in other 1986 NHL for the and 30, potentially (3690 lung between and subjects and exposure women case-control myeloma Registry PD compared sample June exposure HD from occupational sex, association of and NHL factors white and primary with herbicides control age, for with in with of residence multiple exposures risk Cancer cases Canada, to NHL pesticide Saskatchewan, to by of of men of identified of in of 1983, of in 1, cases Population-based study Iowa pesticide Study associated males Regional Sweden Study years) population-based association exposure exposures Study pesticides diagnosed July Study male cancer compared matched location Case-control Case-control Case-control Case-control Case-control 1993 1993 al., 1993 al., al., al., et et et et al., et Brown Persson Semchuk 1993 Zahm McDuffie 1990
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From page 526... ...
526 82 a controls ) (N cancers; other Comparison Group 1,245 82 population 1,245 212 )
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527 based; continues cancers population other 315 164 725 -- 1,128 71 201 1,411 282 two for HD, (2580 in to or (19831986) association residents NHL, chronic association farms of from pesticides STS cancers, years to on United for for compared of NHL of Agriculture cancer population-based 21 study compared (MM)
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From page 528... ...
528 a ) (N Comparison Group 396 275 694 - )
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From page 529... ...
529 continues of area; parts 330 190 465 277 same other 304 (1)
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530 a ) (N Comparison Group 50 338 694 948 )
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531 continues cancers; other general (407) men women 1,683 315 168 228 population 315 85 73 when Smith (133 with update 1983)
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532 a ) (N Comparison Group 2,168 2,936 1,961 127 )
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533 continues 200 92 1,100 2,202 9,654 3,624 NHL prostate stomach MM 98 82 550 1,101 4,827 1,812 in northern to other these men in cancer in with older from population and New with to without stomach or liver association exposure herbicides (19761980) myeloma, including residing (19641978)
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From page 534... ...
534 a ) (N Comparison Group 335 92 3,350 1,651 )
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535 continues 541 311 219 nasal; nasopharyngeal 44 27 134 110 men in for northern acids acids in 1979; between studies for controls abortions for (19781980) population cancer nasopharyngeal 19701979 to to residing occupational births southern paternal occupational and in previous 1981)
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536 a ) (N Comparison Group 154 541 338 2,168 )
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537 206 410 -- Approximately 135,000 were follow for (14,362 52 410 14,788 identified up)
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538 a ) (N Comparison Group -- -- - )
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539 of Agent Disease T3, 1998, for HD, and specifics for proportionate Update hormone; text ,Centers lychlorinated Veterans the fGermany;o chlorophenoxyacetic po PMR, standardized 2001) ; in CDC yl-4 da; VAO, tar SMR, en meth PCDD, (IOM, o; and giv Study; Republic rati 2000 are cutanea thyroid-stimulating 1996)
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From page 540... ...
540 a ) (N Comparison Group 59 None None 59 59 None None 981 )
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From page 541... ...
541 continues 232,745 232,747 232,747 181,579 R R R (28 R B B B B A A A female) 48 A zone zone total zone births zone zone zone births zone 48 zone zone zone zone 74 124 male, zone 804 5,941 38,624 805 5,943 38,625 45,373 805 5,943 38,625 (1)
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542 a in ) (N given Comparison Group 167,391 95,339 Data person-years 123 36 167,391 )
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543 B, continues of Assizio (non-A, subset R adults R) Bristo Cannero 123 12,391 or 241, zone 127 16 60 26 182 R B B R A A A B zone zone zone zone adults zone zone zone zone 152 26 435 2,439 69 528 874 117 19 16 51 146 B, urine over tissue and R an values in nervous among non-A, fetal chloracne, control of and groups zone and to no residents children live were serum measured to activity B and outcomes in normal children of with peripheral occurring to residents Seveso with who zone health of to children enzyme maternal compared among no-chloracne B compared defects of of enzymes children other among measures Seveso mothers mothers and and compared to of community prevalence compared birth R A levels exposed, with hepatic chloracne of of birth analysis areas and of of Seveso of to zone B, laboratory chloracne involvement (19771982)
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544 a ) R (N exposure)
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From page 545... ...
545 continues exposure) births (low 36 241 3,306 104 134 6,690 defects births (high birth hydatidiform 68 exposure)
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546 all but plant and to a ) (N plants region close Municipalities nonexposed Russia Comparison Group 63 164 without 30 living Samara of )
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547 continues by 8,477 coast: bottle-fed 406 10 Internal comparison region West 102 189 68 2,896 226 180 1,822 263 421 325 coast: breast-fed BCC: SCC: 24 HD: NHL: MM: AML: East 105 221 63 cell in to 207 in disease hobby prenatal in basal in factors primary Alberta, of in MM, exposure wood risk with experience southeastern months in immunity primary effects exposure Parkinson's in HD, 18 of (SCC) parameters fishermen to employees patients inhalation NHL, region incidence TCDD study birth of and system of by or compounds Frierfjord cell-mediated center environmental carcinoma cancer Swedish young-onset the study Italy of immunological PCB from effects on care (BCC)
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From page 548... ...
548 a ) (N births incineration non-exposed Comparison Group None 688 No controls -- 71,665 before )
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549 continues national births and 724 State rates 985 15,000 rates births 437 County 187 9,614 -- - in range in high, a cancer dioxin and lip in of live later in or with herbicides national for the other or rates tissue where other areas and occurring in palates to (19791984) exposures palate to state areas cleft county cleft sprayed NHL association to in 19721977 spraying fertilizers of connective outcomes to oral compared for chemical with compared of and excess birth 2,4,5-T 2,4,5-T cases Michigan patients including of STS compared environment low compared England, with living for the potential agricultural association Michigan, adverse prevalence and (19481974)
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From page 550... ...
550 the of O 2000, and Effects disease; a ) area; Update specifics Veterans (N Health lhydrocarbon births -- births -- area for xyresorufun- nson's ary dioxin; 1996, text Comparison Group 1,666 unsprayed 4,120 urban 7-etho Parki p Orange: the in ARNT, PD, Update Agent EROD, given )
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551 for group continues external subjects a ) 1,429 N for analysis ( Comparison comparison Comparison Group 1,776 subjects analysis; comparison internal 1,493 No 1,429 1,052 1,493 )
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From page 552... ...
552 Hand a ) (N Ranch NIOSH Comparison Group 1,086 1,280 227 comparisons 1,275 comparisons 1,299 )
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From page 553... ...
553 counts continues (lymphocyte 1,281 1,197 1,275 1,121 1,186 491 conducted) 1,200 counts (lymphocyte -- 980 871 914 372 conducted)
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From page 554... ...
554 a ) (N veterans offspring children Comparison Group 19,080 1,549 1,254 1,223 1,223 1,276 19,080 )
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555 continues (original (original (participants, (baseline) (provided 1,224 1982)
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556 a ) (N Comparison Group 19,101 1,299 7,364 7,564 1,776 1,776 )
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557 continues children 1,776 1,776 1,972 1,972 1,972 11,910 8,989 4,246 nasal 80 130 48 liver children HD; 342 310 carcinoma; nasopharyngeal carcinoma; primary cancer 2,490 2,490 2,490 12,788 9,324 7,133 of in birth and sarcoma liver sample cancer, enlisted born 1980, between outcomes and nasal Army primary experience children soft-tissue HD, US and of 1968 controls 19651971 of exposure Study -- random outcomes Study: Study: men outcomes study Vietnam psychosocial normal cancer, between sample Orange health and enlisted defects area fathers' Cancers Cancers Experience Agent cases physical reproductive mortality 19651971: birth Army Atlanta Selected Selected nasopharyngeal cancer Vietnam US VES -- random men VES: VES: VES: CDC the comparing potential defects Case- control Case- control Cohort Cohort Cohort Cohort Cohort Case- control al., et a,b 1990c 1990d 1989b 1988a 1988b 1988c 1987; et 1984 CDC, CDC, CDC, CDC, CDC, CDC, CDC, Boyle 1987 Erickson al.,
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From page 558... ...
558 an 111 with colon a ) (N pregnancy hospitalized cancer; with women; women men Comparison Group 2,737 3,038 1,912 indexed 5,946 2,737 269 without patients cancer )
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From page 559... ...
559 continues -- -- 36,797 404 9,346 5,325 311 373 15,000 34,534 33,833 283 10,716 4,586 97 374 and and of to to (1991) Medical Army al.
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From page 560... ...
560 MVA; a Army, STET/OIC ) (N male deaths Marines 27,145 32,422 US Vietnam Vietnam-era Comparison Group 358 2,260 5,324 (1)
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From page 561... ...
561 continues for comparison group -- 1,012 26,685 599 13,496 Study subdivided internal 894 775 24,235 217 234 2,858 and to in race; Armed to referring Agent veterans service (1961 Army the (1968 and of association of with American of serve at Asia Vietnam compared for age exposure veterans not logs compared Vietnam experience by NHL among did of Corps men of likelihood Vietnam-era experience veterans, diagnosed patient in Orange association Southeast US (19651982) who and in in to combat study departments branch Pathology, from Vietnam-era Agent experience mortality Chemical standardized of Vietnam their service with for PTSD veterans or serving of and Vietnam Army among experience Asia (19751980)
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From page 562... ...
562 I II a ) (N deaths Pointman Pointman Comparison Group 3,933 3,933 999 5,229 17 15 )
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From page 563... ...
563 continues male male deaths test deaths white white veteran atomic deceased 5 727 113 veterans 342,654 non-veteran 109,225 other -- 349 male white veteran 2,494 deaths; Vietnam Vietnam veteran male white veterans 214 249 62 110,815 male deaths; white Vietnam-era veteran 923 Vietnam deaths 122,238 era 43,398 veterans 349 to to for and among of to cancers with veterans mortality for men compared compared veterans veterans nonveterans Vietnam-era veterans rare population 1) ; indicator to outcomes compared cancer (19821988)
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From page 564... ...
564 of a ) (N deaths Comparison Group -- 105 2,515 Vietnam-era veterans 17,936 941 186 )
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From page 565... ...
565 continues controls live deceased None 281 130 controls 30 32 66 130 998 2,092 30 32 66 congenital stillbirths neonatal 10,846 281 (1)
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From page 566... ...
566 a ) (N Comparison Group 1,119 -- -- - )
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From page 567... ...
567 continues comparison -- 24,646 -- 281 25,677 25,677 Internal males females 59,036 484 18,949 641 357 19,205 19,205 19,205 in time to of adverse and of of served (1989 veterans for Vietnam outcomes mortality in 1994)
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From page 568... ...
568 the of Safety 2001) ; controls VAO, a )
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