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Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents Appropriate Use of Animal Models (2006) / Chapter Skim
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4 Dosimetry Considerations
Pages 29-32

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From page 29...
... 4 Dosimetry Considerations DOSE METRICS The concept of a "dose metric" (measure of dose, also called an "indicator") has recently been sharpened in relation to monitoring air pollutants (EPA 1996)
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From page 30...
... Infectious Dose Dose is commonly reported as a median lethal dose (LD50) or median infectious dose (ID50)
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From page 31...
... Information about the viability of the agent should be acquired, for example obtaining a measurement of the number of viable organisms, the number of colony-forming unites, or the number of plaque-forming units. Specifics about the experimental design should also be noted or measured, including, details of the generation of the aerosol, particle-size, and exposure characteristics (see Tables 3-1 and 3-2)
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Key Terms

  • experimental design
  • median lethal
  • lethal dose
  • committee recommends
  • infectious dose


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