Path to Effective Recovering of DNA from Formalin-Fixed Biological Samples in Natural History Collections Workshop Summary (2006) / Chapter Skim
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Introduction
Introduction
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. Taxonomists and systematists have developed another application for DNA sequencing: DNA barcoding is a technique for characterizing species of organisms using a short DNA sequence from a standard and agreed-upon position in the genome (CBOL, 2006)
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Development of an effective protocol for recovering DNA sequence information from specimens fixed in formalin and stored in formalin or alcohol will give access to sequence information for thousands of species that are extinct, rare, or difficult to re-collect. WORKSHOP DESCRIPTION At the request of the Consortium for the Barcode of Life, the Museum of Comparative Zoology of Harvard University, the National Evolutionary Synthesis Center, New England Biolabs, Inc., Sigma-Aldrich Company, the U.S.
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. BOX 1-1 Statement of Task for the Workshop on Recovering DNA from Formalin-Fixed Biological Samples Theworkshopwastobringtogetherchemists,biophysicists, biochemists, geneticists, and bioinformaticians to examine past attempts on DNA recovery from formalin-preserved biological specimensanddiscusstheresearchneededtoadvancethedevel opmentofsimilarbutmoreefficientandcost-effectiveprotocols.The goaloftheworkshopwastodeveloparesearchagendathatwill shednewlightontheproblemandleadtoasolution.Amongthe questionstobediscussedattheworkshopwere: · WhatisthestateofpreservationofDNAinthepresence offormalin?
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The workshop convened May 8-9, 2006, at the Keck Center of the National Academies.The participants were the steering committee members; representatives of sponsoring agencies; and others invited because of their expertise in biochemistry and biophysics of nucleic acids, organic chemistry, DNA repair proteins, optimization of DNA extraction, single-molecule sequencing, bioinformatics, mass spectrometry, DNA damage and repair, molecular biology, and taxonomy and systematics (Appendix B)
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