Smart Prosthetics Exploring Assistive Devices for the Body and Mind: Task Group Summaries (2007) / Chapter Skim
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Structural Tissue Interfaces: Enabling and Enhancing Continual Maintenance and Adaptation to Mechanical and Biologic Factors
Structural Tissue Interfaces: Enabling and Enhancing Continual Maintenance and Adaptation to Mechanical and Biologic Factors
Pages 53-60
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From page 53... ...
As a result, long-term incorporation and maintenance of an effective structural tissue interface will depend on the delivery of "just the right" signals. From a design optimization perspective, an approach to the development of robust tissue interfaces would include the fabrication of implants that mimic the structure, mechanical properties, and biologic behavior of native tissue.
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From page 54... ...
What are the morphologic, architectural, and biomaterial features that promote the creation of this biodynamic interface? • The strategies to create lasting interfaces might include the use of engineered materials that are inert or degradeable and induce effective tissue ongrowth or replacement, or the use of biologically based biomaterials that become incorporated and inherently part of the native tissue composite.
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From page 55... ...
At the Keck Futures Initiative Conference in November, task group 6 faced the challenge of defining the characteristics of such a smart structural interface and identifying the gaps in current knowledge and technology that must be closed before a smart interface can be achieved. The first order of business was to define the problem.
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From page 56... ...
But these descriptions seemed too vague, so the group finally settled on a more specific statement: The challenge is to develop a durable structural interface with native tissues and organs that promotes a seamless and interdependent relationship en abling effective transmission of mechanical and biologic factors and signals. The group identified the three key characteristics a smart interface must have as durability, seamlessness, and interdependence with surrounding tissues.
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From page 57... ...
The biopermissive interface must also enable remodeling of both the bone and prosthesis, through biological signaling and interdependent use of synthetic and biologic resources. A seamless and interdependent nerve interface is perhaps the biggest challenge in a smart osseointegrated prosthetic limb.
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From page 58... ...
This includes cellular signaling, nutrient delivery and waste disposal, immune response, and the nervous system, among others. Although we understand much about how these systems function normally or in the presence of foreign bodies, such as an implanted prosthesis, their relationships with one another in the presence of implantable prostheses remain poorly understood.
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From page 59... ...
The interface will have to utilize biological substrates and integrate biological and synthetic materials, such as proteins and synthetic by-products. The actual fabrication and assembly methods will have to be able to simultaneously handle different size scales from nano through macro, and incorporate varying moduli and porosity into the device and interface.
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