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Adverse Drug Event Reporting The Roles of Consumers and Health-Care Professionals: Workshop Summary (2007) / Chapter Skim
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5 Drug-Drug Interactions
Pages 34-39

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From page 34...
... DDIs can be neutral, synergistic, or additive. Preventing medication errors and making appropriate decisions about prescribing drugs for patients who are taking multiple medications will reduce adverse drug events (ADEs)
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From page 35...
... ¥Diagnoses ...... Diagnoses • Outcome ¥ No Incorporate into Incorporate into Incorporate into patient safety Record as Inform Record as patient safety Inform Record as patient safety Inform AE, causality continuous clinicians that continuous AE, causality clinicians that continuous AE, causality clinicians that unknown improvement AE confirmed ADE confirmed improvement unknown improvement cycle ADE confirmed unknown cycl cycl FIgure 5-1 Adverse drug event surveillance: evaluation process in the Duke University Health System.
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From page 36...
... Establishing uniform criteria for drug interactions and adverse drug reactions may address robustness and concordance issues among information sources.
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From page 37...
... Mr. Teagarden expressed hope that the surveillance criteria established would detect adverse events and interactions earlier and also utilize prescribing information to detect drug interactions.
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From page 38...
... communIcatIng Drug InteractIon InFormatIon Patient education is an important step in the reduction of DDIs. For example, one Australian study found that education for physicians that was focused on better use of prescribed NSAIDS reduced the rate of hospital admissions for upper gastrointestinal bleeds by 70 percent (May et al., 1999)
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From page 39...
... He believed that this group could identify and prioritize DDIs, develop a public database capable of receiving all new labeling information on drug interactions, perform an ongoing review of data from the FDA and the published literature, and possibly recommend specific interaction studies. He indicated that a model for the formation of such a group could be found in the National Coordinating Council for Medication Error Reporting and Prevention, an independent partnership of health-care organizations with the goal of reducing medical errors.
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Key Terms

  • drug interaction
  • adverse drug
  • drug reactions
  • adverse events
  • clinical importance

  • drug event
  • patient safety
  • plan sponsors
  • particular drug
  • drug information

  • detect drug
  • interaction information
  • adverse trigger
  • evaluating ddis
  • interaction studies

  • grade causality
  • independent independent
  • condition met
  • uniform criteria
  • ade confirmed

  • safety inform
  • teagarden expressed
  • chart start
  • patient note
  • inform record

  • expressed hope
  • communicating drug
  • perfect drug
  • monitor drug
  • potential drug


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