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36: 452-458. Prepublication Copy 213
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3: 146-154. 214 Prepublication Copy
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Absence of an AEGL-1 value does not imply that exposure below the AEGL-2 concentration is without adverse effects. Prepublication Copy 215
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Scaling: 10 ppm x 6 hour = 60 ppm.hour Uncertainty factors: 3 for interspecies variability 10 for intraspecies variability 10-min AEGL-2 4.0 ppm (30-min value adopted as 10-min value) C x 0.5 hour = 60 ppm.hour 30-min AEGL-2 C = 120 ppm 30 min AEGL-2 = 120 ppm/30 = 4.0 ppm C x 1 hour = 60 ppm.hour 1 hour AEGL-2 C = 60 ppm 1 hour AEGL-2 = 60 ppm/30 = 2.0 ppm C x 4 hour = 60 ppm.hour 4 hour AEGL-2 C = 15 ppm 4 hour AEGL-2 = 15 ppm/30 = 0.50 ppm C x 8 hour = 60 ppm.hour 8 hour AEGL-2 C = 7.5 ppm 8 hour AEGL-2 = 7.5 ppm/30 = 0.25 ppm 216 Prepublication Copy
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C x 0.5 hour = 108 ppm.hour 30-min AEGL-3 C = 216 ppm 30 min AEGL-3 = 216 ppm/30 = 7.2 ppm C x 1 hour = 108 ppm.hour 1 hour AEGL-3 C = 108 ppm 1 hour AEGL-3 = 108 ppm/30 = 3.6 ppm C x 4 hour = 108 ppm.hour 4 hour AEGL-3 C = 27 ppm 4 hour AEGL-3 = 27 ppm/30 = 0.90 ppm C x 8 hour = 108 ppm.hour 8 hour AEGL-3 C = 13.5 ppm 8 hour AEGL-3 = 13.5 ppm/30 = 0.45 ppm Prepublication Copy 217
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Endpoint/Concentration/Rationale: 10 ppm, Exposure was for 6 hours; red mucoid nasal discharge. Uncertainty Factors/Rationale: Total uncertainty factor: 30 Interspecies: 3; Lethality data (45 min.
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Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 6 APPENDIX C CATEGORY PLOT FOR PHOSPHINE Chemical Toxicity - TSD Animal Data Phosphine 1000 100 No Effect Discomfort ppm 10 Disabling Partially Lethal AEGL-3 1 Lethal AEGL-2 0 0 60 120 180 240 300 360 420 480 Minutes FIGURE 10-3 Chemical Toxicity⎯TSD Animal Data Phosphine. 220 Prepublication Copy
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