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Knowing What Works in Health Care A Roadmap for the Nation (2008) / Chapter Skim
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Appendix D: Standards for Reporting Meta-Analyses of Clinical Trials and Observational Studies: QUOROM and MOOSE
Pages 199-204

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From page 199...
... ; methods for validity assessment, data abstraction, and study characteristics, and quantitative data synthesis in sufficient detail to permit replication Results Characteristics of the RCTs included and excluded; qualitative and quantitative findings (i.e., point estimates and confidence intervals) ; and subgroup analyses Conclusion The main results Describe Introduction The explicit clinical problem, biological rationale for the intervention and rationale for review 199
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From page 200...
... , data method of combining results (statistical testing and Synthesis confidence intervals) , handling of missing data; how statistical heterogeneity was assessed; a rationale for any a-priori sensitivity and subgroup analyses; and any assessment of publication bias Results Trial flow Provide a meta-analysis profile summarizing trial flow (see figure)
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From page 201...
... Improving the quality of reports of meta-analyses of randomised controlled trials: The QUOROM statement, 1896 Appendix D 1900, Copyright 1999, with permission from Elsevier. NOTE: The QUOROM Statement is currently being updated under the name PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)
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From page 202...
... in sufficient detail to be replicated Provision of appropriate tables and graphics Reporting of results should include Graphic summarizing individual study estimates and overall estimate Table giving descriptive information for each study included Results of sensitivity testing (e.g., subgroup analysis) Indication of statistical uncertainty findings Reporting of discussion should include Quantitative assessment of bias (e.g., publication bias)
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From page 203...
... Copyright 2000 by American Medical Association. All rights reserved.
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Key Terms

  • randomised controlled
  • study design
  • confidence intervals
  • publication bias
  • observational studies

  • rcts excluded
  • trial flow
  • systematic reviews
  • search strategy
  • study results

  • data synthesis
  • clinical inferences
  • profile summarizing
  • flow diagram
  • discuss clinical

  • giving descriptive
  • articles published
  • descriptive information
  • bias results
  • potential biases

  • combining results
  • uncertainty findings
  • cochrane collaboration
  • controlled trials
  • methodological advances

  • rcts included
  • available studies
  • effects models
  • preferred reporting
  • data abstraction


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