Sequence-Based Classification of Select Agents A Brighter Line (2010) / Chapter Skim
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Appendix G: Influenza A and SARS-CoV
Appendix G: Influenza A and SARS-CoV
Pages 161-162
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From page 161... ...
The effects of restoring a full length functional PB1-F2 protein on 2009 swine H1N1 in vivo pathogenesis are difficult to predict because its virulence-enhancing activities may depend on co-evolutionary changes elsewhere in the genome. As a working model for predicting virulence from sequence information, the preponderance of influenza data suggest that restoration of a full length PB1-F2 protein will enhance the virulence of swine H1N1 -- a hypothesis that will probably be tested using reverse genetics in the near future (McAuley, Zhang et al.)
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From page 162... ...
On the basis of sequence, it was not possible to pre dict that the two highly divergent coronavirus RBDs would engage a similar "hot spot" on the surface of the ACE2 receptor and thus mediate docking and entry into cells. Moreover, the pathogenic potential of the two human coronaviruses are distinct: SARS-CoV causes an atypical pneumonia that results in acute respiratory distress syndrome with mortality exceeding 50 percent in people over 60 years old, whereas NL63-CoV causes a self-limiting denuding bronchiolitis and croup, primarily in infants and children.
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