Sex Differences and Implications for Translational Neuroscience Research Workshop Summary (2011) / Chapter Skim
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6 Needs, Opportunities, and Next Steps
6 Needs, Opportunities, and Next Steps
Pages 73-80
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From page 73... ...
For some diseases, investments in basic science research of nervous system disorders may be more appropriate even if there are known sex differences. In the closing session, Workshop Chairs Stevin Zorn and Rae Silver reviewed the barriers impeding sex differences research that were identified
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From page 74... ...
Participants identified a lack of expertise by study section reviewers in recognizing the importance of sex differences research in funding applications. Another difficulty is that no study section or special emphasis panel exists that specifically funds research on sex differences.
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They also pointed out that workshops, studies, and reports over the past 30 years have drawn attention to the need to address sex differences in health, but few recommendations have been implemented. Contributing to this general disregard for sex differences is the fact the large and influential bodies, such as neuroscience professional societies and journal publishers, have acknowledged sex differences, but have not implemented policies that require researchers to address them.
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From page 76... ...
Many more girls recover within years of stuttering onset, leaving many more boys who stutter by adolescence and adulthood. Research in this area is still in the early stages, but preliminary data show exaggerated deficits in structural and functional connectivity among left hemisphere speech-related regions of the brain in persistently stuttering females compared to persistent males.
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From page 77... ...
• Conduct studies or mine existing data to answer questions regarding female variability due to estrous cycle. Journal Publishers • Develop and institute guidelines for the inclusion of sex-related subject infor mation in all publications, including sex of origin of tissues, cell lines, etc.
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From page 78... ...
Another suggestion by some workshop participants was to issue Requests for Applications for general neuroscience research, outside the context of a particular disease, where a significant sex difference has been identified. Within the NIH the "Blueprint for Neuroscience Research" is a cooperative effort across NIH Institutes and Centers that supports neuroscience research and is aimed at pooling resources and expertise to advance basic and clinical research.
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From page 79... ...
These public information venues present another opportunity to increase understanding of sex differences as they relate to health care. Disseminating Information About Sex Differences: The Roles of Journal Publishers and Professional Societies Suggestions for how journals could foster dissemination of data on sex differences included developing checklists for authors and reviewers to consult when preparing and reviewing manuscripts, and requiring authors to state the potential implications of studying only one sex.
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