Sex Differences and Implications for Translational Neuroscience Research Workshop Summary (2011) / Chapter Skim
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Sex differences are also apparent across the spectrum of health and disease, impacting not only individual health, but also public health, biomedical research, and healthcare delivery. Researchers have begun to elucidate these differences and their potential impact in areas such as pain and pain perception, infection, longevity, disease incidence and course, and cellular response and inflammation.
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SCOPE OF THE WORKSHOP To explore the key principles and strategies that basic and applied researchers are using in the study of sex differences in the neurosciences and in the development of therapies for neurological disorders, the IOM Forum on Neuroscience and Nervous System Disorders convened a workshop on March 8 and 9, 2010, titled Sex Differences and Implications for Translational Neuroscience Research. The Forum was established in 2005 to foster partnerships among stakeholders in the scientific community and the general public; to enhance understanding of research and clinical issues associated with the brain and nervous system and associated disorders; and to advance effective clinical prevention and treatment strategies.
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Stevin Zorn, executive vice president for neuroscience research at Lundbeck and cochair of the workshop, charged participants to address the following questions: • How can the pathway of sex differences research, from basic re search to clinical relevance and ultimately, translation into effective medicines, be made more efficient? • Can the efficiency of diagnostic and treatment strategies be im proved by choosing diagnostic tests, drugs, and/or dosages that consider sex differences?
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An overview of the study of sex differences in biomedical research was provided by experts from four academic institutions and the NIH, and their presentations are summarized in Chapter 2. Discussion focused on the public health importance of studying sex differences in the nervous system, and the potential application of a stronger understanding of these differences to healthcare delivery.
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