Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels Part B (2011) / Chapter Skim
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Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels
Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels
Pages 1-8
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Subsequently, Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances was published in 2001; it provided updated procedures, methods, and other guidelines used by the National Advisory Committee (NAC) on Acute Exposure Guideline Levels for Hazardous Substances for assessing acute adverse health effects.
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Thus, care must be taken in considering deviation or reduction from the default uncertainty factors based on comparison to human data when they do not include the evaluation of the maternal and fetal end points. Specific Comments and Other Comments are provided below for each of the five selected aliphatic nitriles.
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reported high incidence of fetal morphogenic alterations in rats from a single maternal oral exposure at 2,000 mg/kg on gestation day 10. It may be that this study was not included in the TSD because it is not through the inhalation route.
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. As presented under Section I of this document, developmental effects are pertinent systemic toxicity end points, and the consideration for windows of developmental susceptibility supports the use of NOELs from repeated dosing during organogenesis for single-day acute toxicity scenarios (van Raaij et al.
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This value will result in a slightly lower POD than the 1-h POD at 677 ppm in the TSD. As stated in comments under AEGL-2, the personal communication noting no symptoms of cyanide exposure for a "few minutes" at 20-25 ppm in an accidental spill is insufficient to support deviation from the default interspecies uncertainty factor of 10, especially since the TSD notes that rats not being the most sensitive laboratory animal species (page III-20)
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. Page IV-11, lines 16-17, states, "There was no evidence that propionitrile was a selective developmental toxicant." Nevertheless, as presented under Section I of the TSD, developmental effects are pertinent systemic toxicity end points, and the consideration for windows of developmental susceptibility supports the use of NOELs from repeated dosing during organogenesis for single-day acute toxicity scenarios (van Raaij et al.
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In the absence of relevant chemical-specific data for malononitrile, a modification of the AEGL values for acetonitrile was used to derive AEGL-2 and AEGL-3 values for malononitrile. … AEGL-1 values were not derived by analogy due to the uncertainty of extrapolating from lethality to effects defined by AEGL-1.
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Environmental Protection Agency, Washington, DC. October 1994 [online]
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