Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels Part A (2012) / Chapter Skim
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Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels: Part A
Twenty-first Interim Report of the Committee on Acute Exposure Guideline Levels: Part A
Pages 1-24
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on Acute Exposure Guideline Levels for Hazardous Substances for assessing acute adverse health effects. The NRC's previous name for acute exposure levels -- community emergency exposure levels -- was replaced by the term acute exposure guideline levels (AEGLs)
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: acrylonitrile, allyl alcohol, epichlorohydrin, ethylene chlorohydrin, ethyl phosphorodichloridate, hexane, ketene, lewisite, mercaptans (ethyl mercaptan, methyl mercaptan, phenyl mercaptan, and tert-ocyl mercaptan) , methanesulfonyl chloride, methyl isothiocyanate, monoisocyanates (n-butyl isocyanate, cyclohexyl isocyanate, ethyl isocyanate, and phenyl isocyanate)
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TABLE 1 Summary of Proposed AEGL Values for Acrylonitrile Reviewed by the Committee End Point, Classification 10 min 30 min 1h 4h 8h Derivation Factors AEGL-1 1.5 ppm 1.5 ppm 1.5 ppm 1.5 ppm 1.5 ppm No-effect level for notable (nondisabling)
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ALLYL ALCOHOL The committee reviewed the AEGL TSD on allyl alcohol that was presented by Julie Klotzbach of SRC, Inc. Table 2 presents a summary of the proposed AEGL values for allyl alcohol and their basis.
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UF = 30; n = 0.95 for time scaling TABLE 3 Summary of Proposed AEGL Values for Epichlorohydrin Reviewed by the Committee End Point, Classification 10 min 30 min 1h 4h 8h Derivation Factors AEGL-1 1.7 ppm 1.7 ppm 1.7 ppm 1.7 ppm 1.7 ppm No effect level for (6.4 mg/m3)
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The committee reviewed the AEGL TSD on ethylene chlorohydrin that was presented by Julie Klotzbach of SRC, Inc. Table 5 presents a summary of the proposed AEGL values for ethylene chlorohydrin and their basis.
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lethality (BMCL05 of 38 ppm) in rats; UF = 100; default time scaling TABLE 5 Summary of Proposed AEGL Values for Ethylene Chlorohydrin Reviewed by the Committee End Point, Classification 10 min 30 min 1h 4h 8h Derivation Factors AEGL-1 Not Not Not Not Not Insufficient data (nondisabling)
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Table 6 presents a summary of the proposed AEGL values for hexane and their basis. The committee agreed that its previous comments (NRC 2010a)
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Table 7 presents a summary of the proposed AEGL values for ketene and their basis. The committee agreed that its previous comments (NRC 2010a)
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Page 25, line 38: Change to "Office of the Assistant Chief of Staff for Intelligence" MERCAPTANS The committee reviewed the individual AEGL TSDs on ethyl mercaptan, methyl mercaptan, phenyl mercaptan, and tert-octyl mercaptan that were presented by Lisa Ingerman of SRC, Inc. Table 9 presents a summary of the proposed AEGL values for the four mercaptans and their basis.
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TABLE 9 Summary of Proposed AEGL Values for Mercaptans Reviewed by the Committee End Point, Classification 10 min 30 min 1h 4h 8h Derivation Factors Ethyl Mercaptan AEGL-1 1.0 ppm 1.0 ppm 1.0 ppm 1.0 ppm 1.0 ppm No-effect level for (2.5 mg/m3)
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Page 20: The discussion of occupational standards for ethyl mercaptan should provide more context for why they differ from the AEGL values (see earlier section on Comments Relevant to All TSDs)
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Table 10 presents a summary of the proposed AEGL values for methanesulfonyl chloride and their basis. The committee agreed that its previous comments (NRC 2011a)
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concentration in rats; UF = 3; default time scaling MONOISOCYANATES The committee reviewed the AEGL TSD on four monoisocyanates -- n-butyl isocyanate, cyclohexyl isocyanate, ethyl isocyanate, and phenyl isocyanate -- that was presented by Heather CarlsonLynch of SRC, Inc. Table 12 presents a summary of the proposed AEGL values for those monoisocyanates and their basis.
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14 ppm, 4 h; UF = 30; MF = 3; default time scaling Phenyl isocyanate AEGL-1 Not Not Not Not Not Insufficient warning (nondisabling) recommended recommended recommended recommended recommended properties; systemic effects possible at concentrations lower than those associated with irritation.
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(estimated LC01 of 919 ppm) in rats; UF = 10; default time scaling TABLE 14 Summary of Proposed AEGL Values for 3-Quinuclidinyl Benzilate Reviewed by the Committee End Point, Classification 10 min 30 min 1h 4h 8h Derivation Factors AEGL-1 Not Not Not Not Not Insufficient data (nondisabling)
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Table 16 presents a summary of the proposed AEGL values for titanium tetrachloride and their basis. The committee found that its previous comments on the TSD (NRC 2010b)
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. TABLE 16 Summary of Proposed AEGL Values for Titanium Tetrachloride Reviewed by the Committee End Point, Classification 10 min 30 min 1h 4h 8h Derivation Factors AEGL-1 Not Not Not Not Not Insufficient data (nondisabling)
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, including more quantitative context, to support practical implementation of AEGL values. Page 20, lines 24-25: It is unclear why this section is proposed for deletion.
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. Additional information might now be available on titanium tetrachloride because of its use in nanoscale titanium dioxide production.
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repeated-exposure study was used to derive AEGL values. Examples of Potentially Relevant References Not Cited in TSD ATSDR (Agency for Toxic Substances and Disease Registry)
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Table 18 presents a summary of the proposed AEGL values for vinyl acetate monomer and their basis. The committee agreed that its previous comments (NRC 2010b)
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mortality in the rat (78 ppm) ; UF 100; MF = 3; default time scaling TABLE 18 Summary of Proposed AEGL Values for Vinyl Acetate Monomer Reviewed by the Committee End Point, Classification 10 min 30 min 1h 4h 8h Derivation Factors AEGL-1 6.7 ppm 6.7 ppm 6.7 ppm 6.7 ppm 6.7 ppm No-effect level for notable (24 mg/m3)
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2012. Re: Proposed AEGL Value for Allyl Alcohol.
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