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Infectious Diseases of Mice and Rats (1991) / Chapter Skim
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3. Barrier Programs
Pages 17-20

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From page 17...
... An effective or true barrier cannot exist in the absence of a systematic, comprehensive program. Barrier programs consist of several essential elements: stocking with animals known to be free of pathogens, appropriate design of housing environments, rigorous management of the physical plant and caging environments, regular monitoring of pathogen status, and corrective action (e.g., elimination of pathogen-contaminated subpopulations)
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From page 18...
... The principles of barrier maintenance can be successfully applied to individual rooms or groups of rooms within a multipurpose facility; however, even if appropriate operating procedures are followed, the risk of pathogen contamination is greater than it would be in a properly managed barrier facility. Emphasis is given to protecting the room populations from known or potential pathogens in all other rodent populations in the facility.
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From page 19...
... Again, written standard operating procedures are essential. Airflow Systems as Barriers A number of different systems have been developed that use airflow to prevent or control airborne infection of laboratory animals.
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From page 20...
... Disadvantages of LAF and MAF are the added costs of the purchase, maintenance, and operation of the equipment Barrier Cages Filter cage systems provide barriers at the level of the individual cage. Factors that influence cage-to-cage transmission of airborne infection include type of cage used, use of bedding, distance between cages, number of animals per cage, relative humidity, and the generation of airborne dust particles during cage changing and cleaning (McGarrity et al., 1969; van der Veen et al., 1972~.
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Key Terms

  • written standard
  • standard operating
  • pathogen status
  • filtered air
  • defined flora

  • airborne infection
  • intestinal bacterial
  • van der
  • flora animals
  • virus infections

  • barrier facility
  • pathogen contamination
  • bacterial flora
  • research objectives
  • barrier facilities

  • rodent pathogen
  • barrier programs
  • appropriate design
  • entire institutions
  • control airborne

  • corrective action
  • isolators primarily
  • locations accessible
  • experimental population
  • contaminated particulates

  • sendai virus
  • indigenous virus
  • infection include
  • barrier maintenance
  • single cage


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