Medically Assisted Conception An Agenda for Research (1989) / Chapter Skim
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Summary/Scope of the Study
Summary/Scope of the Study
Pages 1-14
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lhe oer~tarpi~r~ of the s ~ y As a workshop at which clinicians and investigators reviewed the stab ~ of assisted conception and The relater basic research in humans a ~ animals, and suggested productive areas for future research. This workshop brought together representatives from the human and animal research worlds to enable them to exchange ideas, enhance their understanding of ways in which they can contribute to each others work, and participate in a joint activity that ~d establish contir~uir~ ties.
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. Alpha data coot describe He emotional toll of infertility, the nications Apia are beginning to portray sax of the distress.
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It will be increasingly important to maximize the r~pr~tive capabilities= of the pry;: available to science. Barriers ~ Ens in In Vitro Fertilization and Embryo Transfer since the birth of Twin Brown in E ~ lard in 1978, in vitro:, fertilization with embryo replacement has become an established method of treatment for certa ~ types of infertility that do nck respond to alternative methods of treatment.
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From page 4... ...
the Feds Goverrment arm Embryo drub Policy conic rewarm on human subjects has Ben sickly evolving singe the 1960s. A sty gnmp was convened atNIH to develop guidelines' arm a National Advisory Fission on Health Science arx]
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From page 5... ...
Domestic ~ Foreign Decisions Concerning Embryo Research The two professional societies ~ the United Stats that represent the physicians most involved in hymen IVFEr have considered ethical questions abort the practice of IVES art - 3ryo research. In 1986 the Remittee on Ethics of the American Cabs - e of C~etricians and Gynecologists (AaDG)
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Deficiencies in the Science Base Pawn; presto at the cammi~ee's workshop art the reseal agenda densely fixes that workshop indicate deficiencies in the scientific urxierpinnir~s of reproductive biology, art identify many areas in whiffs further r~r~ efforts ~1d maim major contributions to improvements in medically autism con ~ ion. The deficiencies are on three levels: basic science knowledge; knowledge needed to improve the technologies being and for medically assisted conception, such as cryobiology; and knowledge needed to improve both human and animal clinical practice of rVFET.
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From page 7... ...
Overviews of the experience gained by the clinical practice of rVFET and of the practice of aniseed conception in food-prc~ucing animals directed attention to unanswered questions that will ~ basic science research for their resolution. These questions reflect important gaps in our knowledge of the biology of all the stages of reproduction from the develcpment of male and female gametes to the process of embryo implantation.
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From page 8... ...
o Devel~nt of ways to produce or synopsize hones frmn non-h~nan primates to be used in ovarian stimulation. O Definition of the role of Croatian estrogen In ocx~e maturation and ovulation are the interactions been estrogen and paracrine factors incl~ir~ fibrdblast ant ppidermal Huh factors, insulin-like!
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O Improvements in embryo multiplication and embryo splitting, especially for food producing animals. Implantation o Definition of the biochemical events that make the uterus permissive to implantation.
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Clinical Research Opportunities lee founding areas are those In which a ooordinated data collection effort across IVAN centers weld help improve the quality arm success rate= of IVES nationally arm, possibly, internationally. O Evaluation of hormonal stimulation protocols in teens of Or of oopytes }vested, quality of oocytes, arm rate of fertilization s~c~cc .
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From page 11... ...
This h? = had undesirable results: Be human clinical practice of Iv~r is To effective En it might have been had reseal pi at a fester pace; other socially~irable goals such as improved con Erosion, better nines to preserve endangers Bier;, and Are c=;t-effective methods of producing food have develc~ed at a pace sicker Can c~timal.
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me ccmmitt== reccrmen~s that a vigorous program of funding for a basic science agenda in reproductive biology be maintained in a coordinated fashion by an appropriate office In the National Institutes of Health. Applied Research Research needs to be stimulated cone rning technologies And In medically assisted conception in food producing animals and in human beings.
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From page 13... ...
Improving Communications The IBM Workshop on Medically Assisted Conception brought together researchers from basic science, clinical practice, and animal sciences. The resulting interaction was viewed as extremely helpful by investigators face each of these communities.
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From page 14... ...
1986. Emit Issues ~ mean In Vitro Fertilization arm Embryo Placerent.
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