Medically Assisted Conception An Agenda for Research (1989) / Chapter Skim
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Paracrine Regulation in the Ovary
Paracrine Regulation in the Ovary
Pages 211-233
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From page 211... ...
:En minion, a ax~sic3erable body of data SLIMS that initial stages of folli~,lar grouch begm before the Cyclic hy~mic~pi - Entity f~c~k Manic are establish art that the initiation of folli=~1ar grew entire to scare extent Hegira periods in Thick pyclic~1 gana~r~n secretion is in ran not (Ri~, 1980~. _ ~ ~ = ~ ~ - =_ ~ ~ _~ ~ Awe pysiologica1 facts r~i~ marian Physiologists to idols illtramarian control systems ran term authorize or paracrine Anion, lc~ before ~ Am; were ~velc~ and polarized.
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From page 212... ...
-these studies, ungirt varietal-= c~inatic~s of ~ins, art, ~tr~ and slid antacid immature a~/or ~ys~ized rats ~~~ a rib for follia~ar <3evelc~ and~cr - In action; In general, a~r~ were found to be inhibitory or attic. he effects of tr~ an gears cull r—licatial In viva Are particularly impressive and these c~;ervatiaY; 1~ to ~ e~ro1utia~ of Me -tatted rat new which has Jaw provided biological malaria for Mantles sties of granule at function In villa.
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From page 213... ...
Me activity of ~tr~2~y1~-~ (E-2 ~ the enzyne responsible for Overtire E to cat ~ olestrogens, is as high or higher in ~ e pa ~ ulatory porcine follicle than in other extrahepatic tissues; importantly, the activity of E-2-M dramatically enhanced An the walls of large well-differentia~c~ ovarian follicles, in the mPmbrana granulnFa in particular, with levels 10-100 fold lower measured in immature follicles and corpora lutea (Hammond et al, 1986~. A physiologist function for the brief surge of catecholestroqan biosynthesis in the preavula~cory follicle has been suited By air sties of the actions of ca~lestr~ens con Turk porcine granule Owls.
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From page 214... ...
~us, Air In beret, and that of of, in the Ovarian Growth factor was stimulated in part By the speculation fat such factors might provide the His by whip pib';tary and g~1 hinges regulated Ovarian ce11 r—1ication. In the years which have folded, immortal actions of Growth factors =~ ~adiffermiciatia~ of Ovarian cells have ^~ beeline augment.
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From page 215... ...
In Batik, the relative inportar~e of the gr~ch-relat~ and c~iffer~iative effects of ~ I0Fs ~ an the level of Greta cliff~tiati~ am the influx of Aver hordes and grad factors ~ et al., 1988b) : ~ the presence of AH and In the milieu of the pr~vulatory follicle, IGFs prance sterai~;is; in the presence of other growth factom m~togenes~s p~irmtes.
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From page 217... ...
However, an understanding of the true significance of these pqpkiAFc will ~ more detailed studies of their nature and regulation. l~nsformir~ Growth Factors beta was initially defined as a peptide whim, in (~xljUrXItiOll off EXJF or ~~ a, allied reversible transformation of normal rat kidney Ills to anchorage irk growth (Spore et al., 1986)
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From page 218... ...
. Ire recently, a stipulatory infraction of Qua ~ FSH con INA Rests by rat granule cells has also been Strafed (Dorri~ et al, 1988~.
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From page 219... ...
Be data available irxlicat~ that ~rera1 Ha; of gram factors are Rested, active, arm probably Important ~ the ovarian follicle. Eta Hurt the IGFs ~ mart complete, arm our level of ~i.rq of me role these phi - ; rivals Cat achieve for steroids.
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From page 220... ...
Ire utilizatic~n of i~i~1 and ~1~1 ar probes for sum previously identified pepti - = has maw Foible a~nJatic~n of information cn goal E~i~X at a lance previously infusible. Variants of this strategy led to identification of many of the ovarian growth factors described previously.
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From page 221... ...
the biochemical Manic whim govern the interplay between z - licati~ arm differentiation of ovarian cells represents a critical topic for further ~ y. A =ivatia, of pret ~ s may be Are fruitful a Breach ~ this area.
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From page 222... ...
-these complex relationships; c- - n well designed for fine ~1 of the Whelming ovarian follicle, ho they may prove fzustratir~ to ovarian physiologists who seek to manipulate than.
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From page 223... ...
~,,3 I a~wledge the helpful its of leer.
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From page 224... ...
T=ns forming grow factors In nc~lastic t;~s and weir rule In Trolling All grow.
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From page 225... ...
1985. Sana~in C aunts ASH ironed differ~iatian of Later zat granule owls.
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From page 226... ...
1986a. Effect of fibroblast grew factor are lipoproteins =~ the p~liferatian of filial Ills wived fun bovine final Carter, brain Forte, are Is luff capillaries;.
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From page 227... ...
1986. Differential effects of transforming growth factor type beta on the growth and function of adrenocortimal cells in vitro.
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From page 228... ...
1983b. E~idermal gem factor ar~ga~ctr - In rel - =ir~han~ irhibit Elicit luteinizir~hozn~e Air formation in mar; granule cells.
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From page 229... ...
1988. ~3al and exczagcmadal expression of ir~ibin al;~a beta-A and beta-B ~its in varia~s tia~ predicts diverse furx tia~s.
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From page 230... ...
1987. Clean pibl;tary and playful hormones ~ro1 human insuli~like grab factor II secretion In human Grandly Owls.
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From page 231... ...
1987. Catechol estrogens stir Hate progestin secretion by cultured porcine granNl06a cells.
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From page 232... ...
1985. A Hole for Dana; C as a differ~iatir~ honoree art a - lifier of hormone action con ovarian cells: S~i~ ~= syr~heti~1ly Are hen sand din C arx]
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From page 233... ...
1987. Coordinate typic dry regulation of Is for insulin~like gray factor IT art the ~les~1 si~ain~l~vage ~ P450ssc, in Amen sonic times.
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