Medically Assisted Conception An Agenda for Research (1989) / Chapter Skim
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The Fertilizing Sperm: Structure, Maturation and Function
The Fertilizing Sperm: Structure, Maturation and Function
Pages 250-261
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From page 250... ...
But for scare Sian species, incl~ir~ the Han, it ~ diffir~S,Qt to cony novel, foal Beam due to limi~tians of material as well as ethical =iderati~. Bus, it be; important to evaluate ache anion Gel Stems urger stay Firstly for them a~r~riater~; in ~i~ the Lear basis of lien gamete interaction Gently.
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From page 251... ...
these sternal features of acre exits are Extant for all Sian Term spied Pus far. CX~N AWE; IN LIE Hill SI=:ENCE: OF ~ ~='1= Formation m~nir~ Me molar organization ark condition of Me Gates' surfaces Is essential for an Slid of they int~ctic~n.
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From page 252... ...
_,= = ~ In initial systematic studies using made gametes, and considered contrcversial for some ties, it Is found that fertilizing sperm initiate birding to the up win ache ploy me—cane in the acreage ir~cacL state. fitly, He same firers have- ~ for a large fir of fiord spies (Table 1)
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From page 253... ...
cow hamster human masse rabbit The mal^~,lar events sucrcunLing the AR are not Understood fully, but recent work implicates mechanisms common to other receptor~effec* or Is, sum as hand arm grad fac*
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From page 254... ...
Fusion Hen prams.= to incorporate He Bin sperm into the Blown of He egg, except for ache inner act Membrane whim does not fuse, hit ~ inc=rpo~ted into a p~eic vesicle. A GENES L ~ ION GAME: INrE~Ac=m these remet irnrestigatia~s at the cellular and Alar levels praise sufficient data to sagest a ~ of gate interactions that may ably generally to Canals.
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From page 255... ...
hybrid vesicles bearing sperm r~ far Zen remain at Ye up Sofas' and Satire can be seen as a odor thresh which the exam penetrate.
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From page 256... ...
Similarly, with rears kinetics, perhaps ZP3~ti~1at~ ARs Ear sufficiently slowly in Ease Glenn to permit e~peri~tal d~ervaticn Woo the En is bound to the up surface, Whereas in many ather Species the event Is more difficult to detect due to rapid AR induction at that location. Species variations mill be observed, but it seems unlikely that the== mill involve major differences in fundamental design or mechanism, but rather variations in the affinity or kinetics of individrm~ events.
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From page 257... ...
~ anticipate that Axe miles involved ~ rendition evens, which are likely to be present in leer aunts, will be ammo those that da~trate species differences. Her, the abated ~nfonnati~ derive fray eral Martian ins rats that be HAL likely lattice for sperm Alleles involve in primary interactic~n with e 8p, for beta ~ , is the pi a ~ Drone averlyir~ the acz ~ ane.
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From page 258... ...
. They have identified a mAb ~ t guinea pig sperm that blocks fusion with the egy plasma membrane, but only in a heterologous cross (guinea pig sperm + hamster eggs)
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From page 259... ...
As, Dies in my ~ have predict, arm are ~;rui~ to provide, an invaluable body of information Ox cellular are ~lea~lar ~ ~ which fertilization axons. Here ~ no Seine for the sty of hcnx~l~ws Gates in physiological Clitics to identify individual Axles At participate In Gate interaction, ho ex~ive sties In m~e]
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From page 260... ...
Sari, ed. If: Japan Scientific Society Pres;.
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