Medically Assisted Conception An Agenda for Research (1989) / Chapter Skim
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IV. Research Agenda and Recommendations
IV. Research Agenda and Recommendations
Pages 86-94
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From page 86... ...
me third category includes questions that can be approached tar Operative agreements ~ng - In addition to organizing the rearm agenda ink Camden areas, these categories also genially reflect the different furring Humanisms that might be r~ui~ to support such investigations. Reseal grants to short basic science proteges c~ct be obtained through competitive grant programs at the National Institutes of Hearth or the National Science Fcun~ation.
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From page 87... ...
O Definition of ~ e role of ovarian estrogen in ooc ~ e mab~ration and cvulation and the interactions between estrogen and paracrine factors including fibroblast and epidermal growth factors, insul Unalike Growth factor, transforming growth factor, and inhib~n. O Definition of the point at which oocybes become sensitive to factors that influence their development.
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From page 88... ...
O Assessing the potential of individual embryonic reals and defining the point at which embryonic meals are committed to particular fates. O Identification of substances procure by early embryos that signal~changes An the uterus prior to implantation.
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From page 89... ...
Clinical Research Opportunities m e following areas are thou in which a coordinated data collection effort across [VFET clinical centers would improve the quality and success rates of IVFET nationally and, possibly, internationally. O Evaluation of hormonal stimulation protocols in terms of namer of oodles handy, quality of of;, and rate of fertilization sums .
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From page 90... ...
This has had urxI-=irable r ~ ts: the human clinical practice of [VFET is less effective than it might have been had research progressed at a faster pace; other socially desirable goals such as improved contraception, better techniques to preserve endangered species, and more cost-effective methodic of producing food have develcged at a pace slower than is Optimal. m e recent appointment of the Bicmedica1 Advisory Commit ~ e by the Bicmedi~al Ethics Board, to report to Congress by November 1990 on embryo research issues, could be a step toward a solution.
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From page 91... ...
The group has a mandate to remake five major activities: 0 to approve a ~ of practice can r~r~ relate to Hun fertilization arm embryology; o to invite all centers, clinicians and scientists engaged in research on IVF to submit their work for apprcNa1 and licensing; o to visit each center before it is granted a license; o to report to the sponsoring organizations; and o to make known publicly the details of both approved and unapproved work. Basic Science Foundations The number and range of topics included in this chapker's research agenda indicate the exciting potential for prc~uctive scientific exploration.
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From page 92... ...
me Remittee Hers that a vigorous program for fur~irn of a basic science agenda ~ pr reductive biology be maintained In a ~ rdinated fashion by an appropriate office in the National Institutes of Health. Applied Breath Research neons to be stimulat ~ concerning technologies used in medically assisted conception ~ food producing animals and in human beings.
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From page 93... ...
What is the role of Institutional Review boards in the establishment and maintenance of clinical facilities? Some specific que ~ ions to be answered frill data that could be collected frog clinics include: What ovarian stimulation protocols are the most successful?
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From page 94... ...
On ache animal side, He American Embryo Transfer Society has start to establish sane Parity Ares for cxx~remialbavineen~ryo transfer. States ~ngereral get involved by limping physicians, hospitals, art clinics, art as yet have net played a dominant role In assuring quality of Am.
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