Biographical Memoirs Volume 58 (1989) / Chapter Skim
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Moses Kunitz
Moses Kunitz
Pages 304-317
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In the fall of that year, he enterer! the Electrical Engineering School of Cooper Union, where he studied until 1919 when he transferred to the Columbia University School of Mines Engineering anti Chemistry.
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while working full time as a technical assistant in Jacques Loeb's general physiology laboratory at the Rockefeller Institute for Medical Research. Loeb quickly recognized Kunitz's fine work habits ancT encourages!
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He then used the protease to convert trypsinogen to trypsin in an acid medium, obtaining a cleaner preparation of trypsin than was possible by any previous procedure. The presence of substances inhibitory to trypsin in the original pancreatic extracts, and in certain soybean meal fractions, led Kunitz to the crystallization of a polypeptide inhibitor from the pancreas and a protein inhibitor from soybean.
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One of his finest papers details the study of the kinetics and thermodynamics of the reversible denaturation of the soybean trypsin inhibitor. From 1939 to 1940, Kunitz worked to isolate ribonuclease from beef pancreas.
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Kunitz possesses to a rare degree the abilities of a research worker of the first rank in his chosen field imagination, ingenuity, persistence, great technical skill, mathematical facility, and a thorough theoretical knowledge. It is not surprising, therefore, that he has been able to solve almost every problem he has attempted.
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310 BIOGRAPHICAL MEMOIRS nuclease, hexokinase, and deoxyribonuclease placed the protein nature of enzymes, in general, on a firm experimental foundation. In addition, the nucleases have been invaluable tools in the elucidation of the chemistry of the nucleic acids, those remarkable substances that appear to be the very 'stuff of life'." Moses Kunitz was a modest, gentle, considerate person who loved his work and his family.
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He was elected to the National Academy of Sciences in 1967 and received an honorary degree from The Rockefeller University in 1973. He was a member of the American Association for the Advancement of Science, the Society for Experimental Biology, the American Society of Biological Chemists, and the Society of General Physiologists.
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III. The influence of salts on osmotic pressure, membrane potentials, and swelling of sodium gelatinate.
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Isolation of protein crystals possessing tryptic activity. Science, 73:262-63.
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Die Isolierung von kristallisiertem Trypsinogen und dessen Umwandlung in kristallisiertes Trypsin.
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Isolation from beef pancreas of crystalline trypsinogen, trypsin, a trypsin inhibitor, and an inhibitortrypsin compound.
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The kinetics and thermodynamics of reversible denaturation of crystalline soybean trypsin inhibitor.
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I Isolation and general properties; spectrophotometric method for the measurement of desoxyribonuclease activity.
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