Biographical Memoirs Volume 58 (1989) / Chapter Skim
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William Christopher Stadie
William Christopher Stadie
Pages 512-528
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From page 513... ...
In the third, Stadie made major contributions to our knowleclge of the abnormalities of carbohydrate metabolism and diabetes. For many years, Bill Staclie and ~ had adjacent laboratories on the eighth floor of the Maloney Builcting of the University Hospital and we usually lunched together.
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From page 514... ...
that Bill hacl helped finance his education while a medical school undergraduate by typing the manuscript of McCallum's well-known pathology text. After a stint in the Army Medical Corps during World War I, Staclie's successful internship at the Presbyterian Hospital won him a research job at the Hospital of the Rockefeller Institute, where a group was being organized to study the newer treatments of syphillis.
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From page 515... ...
Though he had retired from teaching in 1956, Stadie continued as the Musser Professor Emeritus and was actively engaged in research at the time of his death, at the age of seventy-three, in 1959. After his grouncibreaking discoveries in oxygen therapy ant!
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From page 516... ...
He further demonstrated that the hyperketonemia of animals with acute experimental diabetes results primarily from hepatic overproduction of ketone bodies rather than from a defect in their utilization. Stadie adduced an important part of the evidence on which presently accepted views regarding diabetes are based: that the liver splits fats almost quantitatively into acetoacetic and hydroxybutyric acid, which are circulated to the other tissues for combustion; that the muscles of a diabetic can burn acetoacetic acid at a normal rate; and that excretion of acetoacetic and hydroxybutyric acids occurs in diabetes when carbohydrate is not available for combustion because these acids are formed faster than the tissues can burn them.
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From page 517... ...
was eclitor-in-chief of the American Diabetes Association journal, Diabetes, for the last three years of his life. Electect to the National Academy of Sciences in 1945, Stadie received the Alverenga Award of the Philadelphia College of Physicians in ~ 957, the Phillips Medal of the American College of Physicians in 1941, the Kober Medal of the Association of American Physicians in 1955, and the Banting Medal of the American Diabetes Association in 1956.
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From page 518... ...
Suffering from mild angina pectoris occasionally for several years, he cried of a heart attack. His refined experiments, which so much advanced his fielcis of interest, will live long after him.
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From page 519... ...
Chem., 49: 1. A mechanical shaker and other devices for use with the Van Slyke blood gas apparatus.
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From page 520... ...
III. The validity of hydrogen ion activity determinations by the hydrogen electrode in systems containing carbonic acid, carbonates, hemoglobin, carbon monoxide hemoglobin, and me/hemoglobin.
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From page 521... ...
The role of the liquid junction potential in the electrometric determination of single ion activity coefficients.
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From page 522... ...
The catalysis of the hydration of carbon dioxide and dehydration of carbonic acid by an enzyme isolated from red blood cells.
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Zapp, {r. The action of insulin upon urea formation and carbohydrate synthesis by liver slices of normal and diabetic animals.
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Zapp, fir. The equilibrium relations of d-amino acid oxidase, flavin adenine dinucleotide and amino acids from kinetic data.
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1945 The intermediary metabolism of fatty acids. Physiol.
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The effect of insulin and adrenal cortical extract on the hexokinase reaction in extracts of muscle from depancreatized cats.
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Relation between glycogen content and synthesis of fatty acids by rat liver.
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From page 528... ...
N Shawl Two identical Embden-Meyerhof enzyme systems in normal rat diaphragms differing in cytological location and response to insulin.
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