Mapping the Brain and Its Functions Integrating Enabling Technologies into Neuroscience Research (1991) / Chapter Skim
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The Brain Mapping Initiative: Committee Conclusions and Recommendations
The Brain Mapping Initiative: Committee Conclusions and Recommendations
Pages 113-130
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From page 113... ...
Neuroscience, like many other scientific fields, is divided into a range of specialties. The diversity of research methods generated by such specialization makes it unlikely that any one individual can achieve sufficient expertise in every method to allow for a learned interpreta113
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From page 114... ...
Therefore, the committee recommends that the Brain Mapping Initiative be established with the long-term objective of developing three-dimensional computerized maps and models of the structure, functions, connectivity, pharmacology, and molecular biology of human, rat, and monkey brains1 across developmental stages and reflecting both normal and disease states. The committee envisions this objective to be accomplished in two
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From page 115... ...
In addition, pilot projects would bring focus and utility to information technology research in areas useful to neuroscience research. Phase 2 would be the construction of a complete family of maps and models all the elements necessary to provide a complex of electronic resources to enhance neuroscience research.
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From page 116... ...
The committee recommends the establishment of pilot projects or consortia. These projects should be peer-reviewed by neuroscientists and computer scientists; they should also be investigator initiated, involve geographically dispersed laboratories, and include neuroscientists with varied levels of computer experience.
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From page 117... ...
Each of these database forms needs to be thoroughly investigated by phase 1 projects; however, certain resources should be implemented immediately. The committee recognizes that neuroscience efforts proceed internationally and recommends that an international registry of neuroscience databases and contacts be established so that appropriate linkages can be created in the future.
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From page 118... ...
Understandable sensitivity exists in such areas, and careful attention to these issues is necessary for those involved with the development and planning of electronic resources. Including investigators with different levels of computer expertise in phase 1 projects will facilitate greater acceptance of computer technology by emphasizing the varied needs of the neuroscience community and opening important channels of communication.
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From page 119... ...
Another important sociological issue facing phase 1 projects is the acceptance of standards for data representation, data entry, nomenclature, and methods of data annotation. Currently accepted methods of representing data lack the level of precision required for coordinated computer resources.
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From page 120... ...
Computer networks are the second technical requirement area to be considered. The future of national and international computer networks is particularly promising for the development of a brain mapping effort.
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From page 121... ...
The panel would be responsible for the overall direction, evaluation, and coordination of consortia and for the development of necessary policies relating to establishment of a brain mapping effort. The committee also recommends that the Advisory Panel be responsible for consideration and development of editorial functions and policies relating to the ethical and sociological issues that will arise, including, but not limited to, correctness of information and quality control, intellectual property rights, rights to privacy, and freedom of information.
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From page 122... ...
In addition, the coordination of phase 1 projects with other national and international efforts is extremely important. Therefore, the committee recommends that the phase 1 and 2 projects of the Brain Mapping Initiative maintain a close relationship with the gene mapping and sequencing community and
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From page 123... ...
Therefore, the committee recommends that federal funding agencies develop requests for applications and/or cooperative agreements to support the formation of consortia and the activities of the Brain Map Advisory Panel. Limited use of contract mechanisms should also be considered when appropriate to the overall goals of the initiative.
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From page 124... ...
, constitute a structure the committee considers essential to the success of the Brain Mapping Initiative. Such a structure, however, will require flexibility in the typical biomedical funding mechanisms noted above and cooperation among different agencies.
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From page 125... ...
Therefore, the committee concludes that the expected benefits of the proposed Brain Mapping Initiative justify the investment of necessary resources and recommends the appropriation of additional funding to support the establishment of phase 1 projects. Phase 1 projects wi// require a certain amount of time and support Five years is the minimum time that should be allowed for phase 1 projects to reach the level of expertise and technological development necessary to initiate phase 2.
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From page 126... ...
The proposed Brain Mapping Initiative will allow investigators studying the brain to view data in new ways, to share data with each other, and to access needed data from any of the neuroscience subspecialties. So enabled, neuroscientists will map the brain and its functions to a degree only faintly imaginable even 20 years ago.
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From page 127... ...
The committee recommends that the Brain Mapping Initiative be established with the long-term objective of developing three-dimensional computerized maps and models of the structure, functions, connectivity, pharmacology, and molecular biology of human, rat, and monkey brains across developmental stages and reflecting both normal and disease states. The committee envisions this objective to
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From page 128... ...
6. The committee recommends that the phase 1 and 2 projects of the Brain Mapping Initiative maintain a close relationship with the gene mapping and sequencing community and the Human Genome Project, and with other scientific computing efforts, including network initiatives such as NSFNET and the proposed National Research and Education Network.
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From page 129... ...
9. The committee concludes that the expected benefits of the proposed Brain Mapping Initiative justify the investment of necessary resources and recommends the appropriation of additional funding to support the establishment of phase 1 projects.
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