The National Academies Press

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1 Introduction
Pages 15-34

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From page 15... ... . Despite the production of new data and numerous publications disseminating these research findings, translating the results of basic and clinical research into clinical and community practice has been slow and cumbersome, and many years may pass before the benefits of basic science discoveries and clinical investigations reach individual patients and communities. Read the entire page →
From page 16... ... . Consistent with NIH's Roadmap, the CTSA Program's initial goals were to  "create academic homes for clinical and translational research;  provide investigators and research teams with research cores, tools and a local environment that encourages and facilitates the conduct of clinical and translational research, including with community and industry partners; and  train the scientific workforce needed for the translational sciences" (NCATS, 2013a) Read the entire page →
From page 17... ... directed it to assess the CTSA Program and its mission and strategic goals and to offer advice on the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) , while exploring the contributions of CTSAs in accelerating the development of new therapeutics, facilitating disease-specific research and child health research, and enhancing the integration of research funded by NIH institutes and centers. Read the entire page →
From page 18... ... will assemble an ad hoc expert committee to provide an independent appraisal of and advice on the NIH Clinical and Translational Science Awards (CTSA) Program as it will be implemented by the newly formed National Center for Advancing Translational Sciences (NCATS) Read the entire page →
From page 19... ... related to the CTSA Program, information submitted by a range of CTSA Consortium committees and stakeholder groups, and data and recommendations from other relevant working groups and stakeholder meetings. The committee's work was also informed by responses to a series of public input questions that focused on the CTSA Program's mission and strategic goals and its role in advancing research along the continuum of clinical and translational science.1 CLINICAL AND TRANSLATIONAL RESEARCH Translational research means different things to different people but it seems important to almost everyone. Read the entire page →
From page 20... ... . Although the depiction of the separate phases of translational research above suggests a linear model with a finite beginning and end, in reality the operational phases of translational research include many feedback loops. Read the entire page →
From page 21... ... community, in turn, informs the work in the laboratory. As a result, the impact of translational research on health improvements hinges on an integrated and responsive research infrastructure, similar to models of a "learning health care system" (discussed in Chapter 2) Read the entire page →
From page 22... ... . In 2006, 12 CTSA sites were funded through 5-year cooperative agreements as a first step toward establishing academic homes for clinical and translational research (Briggs and Austin, 2012; NIH, 2005; OIG, 2011) Read the entire page →
From page 23... ... . The NCATS mission focuses on catalyzing innovative methods and technologies related to the development of diagnostics and therapeutics, and it became home to the CTSA Program and several smaller, related NIH programs. Read the entire page →
From page 24... ... . The program has a complex, multilevel organizational and oversight structure involving individual institutions, the CTSA Consortium, the CTSA Coordinating Center, and NCATS. Read the entire page →
From page 25... ... . CTSA Consortium Committees and Coordinating Center CTSA Consortium committees From the outset of the program, the NIH charged the CTSAs with developing a national consortium to promote the identification and use of best research practices (Berglund and Tarantal, 2009) Read the entire page →
From page 26... ... . Fourteen key function committees discuss crosscutting issues, promote collaboration, and identify and implement best practices. Read the entire page →
From page 27... ... The committees comprise PIs and researchers who take on these extra responsibilities in addition to their work at their institution's CTSA. BOX 1-3 CTSA Consortium Committees and Working Groups Consortium Leadership Committee  Consortium Executive Committee  Consortium Steering Committee  CTSA Consortium Child Health Oversight Committee Consortium Strategic Goal Committees  Strategic Goal Committee 1 -- National Clinical and Translational Re search Capability  Strategic Goal Committee 2 -- Training and Career Development of Clinical/Translational Scientists  Strategic Goal Committee 3 -- Enhancing Consortium-Wide Collaborations  Strategic Goal Committee 4 -- Enhancing the Health of Our Communi ties and the Nation  Strategic Goal Committee 5 -- T1 Translational Research Key Function Committees  Administration Key Function Committee  Biostatistics/Epidemiology/Research Design Key Function Committee  Clinical Research Ethics Key Function Committee  Clinical Research Management Key Function Committee  Clinical Services Core Key Function Committee  Communications Key Function Committee  Community Engagement Key Function Committee Read the entire page →
From page 28... ... TABLE 1-1 Alignment of the CTSA Key Function Committees and Strategic Goal Committees Strategic Goal Committees 1 2 3 4 5 Key Function Committees That Support Strategic Goal Committees Clinical Research Management X Clinical Services Core X  Regulatory Knowledge X Education and Career Development X   Community Engagement X Comparative Effectiveness Research X Public–Private Partnerships   X Translational X Communications  X   Crosscutting Key Function Committees Informatics      Evaluation      Biostatistics/Epidemiology/Design      Clinical Research Ethics      Read the entire page →
From page 29... ... . CTSA Consortium Coordinating Center In November 2011, the CTSA Consortium Coordinating Center was established through a competitive application process, which awarded Vanderbilt University a budget of $20 million over 5 years to  establish a high visibility and accessible "national home" for the CTSA Program;  manage meetings, projects, and communications of the CTSA Consortium;  compile and organize the CTSA Consortium's networking re sources; and  develop and disseminate research tools and resources that sup port translational research (CTSA Central, 2013d; Snyder, 2011) Read the entire page →
From page 30... ... 2012. Unraveling the autoimmune translational research process layer by layer. Read the entire page →
From page 31... ... 2013d. CTSA Consortium Coordinating Center (C4) Read the entire page →
From page 32... ... 2013. Translational research: T-phases of translational health research. Read the entire page →
From page 33... ... 2010. Reengineering the national clinical and translational research enterprise: The strategic plan of the National Clinical and Translational Science Awards Consortium. Read the entire page →
From page 34... ... Translational Research 148(1) Read the entire page →

From page 15...

... . Despite the production of new data and numerous publications disseminating these research findings, translating the results of basic and clinical research into clinical and community practice has been slow and cumbersome, and many years may pass before the benefits of basic science discoveries and clinical investigations reach individual patients and communities.

1 Introduction Pages 15-34

1 Introduction
Pages 15-34