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Neurodegeneration Exploring Commonalities Across Diseases: Workshop Summary (2013) / Chapter Skim
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7 Closing Remarks
Pages 65-68

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From page 65...
... Many participants noted the importance of further research within individual diseases. The observation of common mechanisms, pathologies, and genetics across different diseases suggests that it may be valuable -- at least in cases where careful scrutiny and consideration of the evidence supports it -- to move away from the tradition of studying individual diseases and instead consider whether they may be better understood as clinical variants of common cellular and molecular biological defects.
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From page 66...
... In thinking about promising strategies going forward, several participants discussed the balance between going after a single receptor or single transcription factor versus embracing complexity. One participant noted that although the intrinsic complexity may be concerning to large pharmaceutical companies and a single focus may provide the appealing promise of clarity, the biological phenomena themselves may require a systems approach.
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From page 67...
... Lucie Bruijn of the ALS Association also emphasized the need for further careful exploration of the commonalities and differences among diseases, before launching large projects based on perceived commonalities across multiple diseases. In closing the workshop, Landis reminded the group of the provocative questions process that Harold Varmus implemented as director of the National Cancer Institute, and challenged participants to design a similar set of questions focusing on neurodegenerative diseases and basic cell biology of neurons.
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Key Terms

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  • als association
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  • diseases suggests

  • academic investigators
  • pharmaceutical companies
  • neuroimaging initiative
  • effectively treat
  • multiple diseases

  • tems approach
  • challenged participants
  • ticipants suggested
  • approach expand
  • therapeutics development

  • pursuing cns
  • called adni
  • neurodegenerative disease
  • participants discussed
  • participant noted

  • cell biology
  • advance efforts
  • questions process
  • landis reminded
  • target gene

  • similar set
  • phenomena themselves
  • single transcription
  • multifactorial etiology
  • ticipants discussed


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