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The process of discovering and developing a safe pesticide
Pages 4-6

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From page 4...
... Number of applications and, particularly, the date of last application THE PROCESS OF DISCOVERING AND DEVELOPING A SAFE PESTICIDE Chemicals for use in agricultural pest control are discovered by extensive testing of materials from four sources: 1. Inorganic compounds usually containing a metal or sulfur but no carbon or nitrogen 2.
From page 5...
... By the time one successful compound is conceived of by a chemist, evaluated by a biologist, synthesized commercially by chemical engineers, evaluated for field performance by industry and public agencies, certified for activity by government, and shown to be safe for use, a bill of one to two million dollars may have been incurred. This includes not only the actual cost of the one successful compound but also the costs incurred by all the failures encountered.
From page 6...
... After extensive small-plot field trials have indicated that a material is an effective pesticide and may be commercially developed, it should be subjected to feeding tests on animals to determine subacute and chronic toxicity. While the chronic toxicity tests are in progress, analytical procedures must be perfected and data obtained on residues remaining in or on the edible portions of various crops at harvest time.


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