Safe Use of Pesticides in Food Production; a Report [by] W.J. Darby, Chairman ... [Et Al.] (1956) / Chapter Skim
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Data required before marketing a new pesticide
Data required before marketing a new pesticide
Pages 7-14
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From page 7... ...
OTENTIALITIES OF N! INARY SCREENING FOR TICIDAL ACTIVITY o a •55 1 mination of Chemical Physical Properties 3 Process De\ Pilot P 1 L_ nary Estimate of Safety for Residue to Iti CJ *
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From page 8... ...
The manufacturer must assume, in addition to his responsibility with respect to public health, the usual responsibility for performance of the product as claimed. He should be granted reasonable freedom to incur well calculated risks pertaining to crop damage and performance of the material as a pesticide.
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From page 9... ...
Supplemental information accompanying experimental data should provide a comprehensive description of the material and its use and should include the following points where applicable: a. Names and percentages of active ingredients and such additional information as is necessary for proper evaluation for ultimate commercial use.
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From page 10... ...
These data, which may be obtained by analyzing representative crop material harvested from the tests on pesticidal effectiveness, should show the total amount of chemical found on and/or in a stated weight of the food product. Fewer residue data will be required for pesticides that are not toxic to warm-blooded animals at recommended use levels, are highly volatile or otherwise non-residual, or are decomposed to nontoxic components before harvest.
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From page 11... ...
Such considerations may influence the choice of a test animal in order to obtain information in the most sensitive species. The dosage levels investigated should range from an absence of the pesticide in controls through a series of intermediate levels and through at least one producing significant effects.
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From page 12... ...
The subacute feeding tests with rats may be so designed that enough rats are used at each dietary level to provide animals to be continued in tests for chronic toxicity, in the event it becomes advisable to conduct such tests.
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From page 13... ...
Observations are similar to those made in the chronic feeding test with rats. The dog or monkey tests are generally started after the rat studies have been in progress long enough to provide data to aid in selecting the feeding levels likely to be most informative.
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From page 14... ...
Before any new pesticide can be moved in interstate commerce it must be registered with the Pesticide Regulation Section, Plant Pest Control Branch, Agricultural Research Service, USDA, under terms of the Insecticide, Fungicide, and Rodenticide Act. The registrant must present data such as those suggested in the preceding section to prove its usefulness, safety to the public when label precautions are followed, compatibility on various crops as recommended, and safety of the treated crop product for use as a livestock feed or food for human consumption.
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