Medically Assisted Conception An Agenda for Research : Report of a Study (1989) / Chapter Skim
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RESEARCH AGENDA AND RECOMMENDATIONS
RESEARCH AGENDA AND RECOMMENDATIONS
Pages 86-95
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From page 86... ...
In addition to organizing the research agenda into common areas, these categories also generally reflect the different funding mechanisms that might be required to support such investigations. Research grants to support basic science projects could be obtained through competitive grant programs at the National Institutes of Health or the National Science Foundation.
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From page 87... ...
o Definition of the role of ovarian estrogen in oocyte maturation and ovulation and the interactions between estrogen and paracrine factors including fibroblast and epidermal growth factors, insulin-like growth factor, transforming growth factor, and inhibin. o Definition of the point at which oocytes become sensitive to factors that influence their development.
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From page 88... ...
o Determination of the physiological significance of germinal vesicle breakdown and the biochemistry of sperm chromatin decondensation. o Definition of the molecular events associated with formation of the male and female pronuclei.
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From page 89... ...
o Development of safe methods of biopsy of early embryos for preimplantation diagnosis of genetic ftintvnen. Clinical Research Opportunities The following areas are those in which a coordinated data collection effort across IVFET clinical centers would improve the quality and success rates of TVFET nationally and, possibly, internationally.
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From page 90... ...
This has had undesirable results: the human clinical practice of IVFET is less effective than it might have been had research progressed at a faster pace; other socially desirable goals such as improved contraception, better techniques to preserve endangered species, and more cost-effective methods of producing food have developed at a pace slower than is optimal. The recent appointment of the Biomedical Advisory Committee by the Biomedical Ethics Board, to report to Congress by November 1990 on embryo research issues, could be a step toward a solution.
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From page 91... ...
Basic Science Foundations The number and range of topics included in this chapter's research agenda indicate the exciting potential for productive scientific exploration. Funding that would allow investigation of the areas targeted in the research agenda would allow significant advances to be made in understanding reproductive processes.
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From page 92... ...
basic science agenda in reproductive biology be maintained in a coordinated fashion bv an amrooriate office in the National Institutes of Health. Applied Research Research needs to be stimulated concerning technologies used in medically assisted conception in food producing animals and in human beings.
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From page 93... ...
Coordinated studies utilizing the mass of material and experience from IVFET centers could begin to answer these and other questions. In addition, the experience of centers performing IVFET for farm animals could provide valuable information.
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From page 94... ...
Improving Connunications The ICM Workshop on Medically Assisted Conception brought together researchers from basic science, clinical practice, and animal sciences. The resulting interaction was viewed as extremely helpful by investigators from each of these cxnttunitd.es.
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