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A Framework to Guide Selection of Chemical Alternatives (2014) / Chapter Skim
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Appendix C Toxicological Priority Index (ToxPi)
Pages 247-252

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From page 247...
... While reducing the various types broad category, "in vitro assay data," integrates data of information into one number could obfuscate the from six independent assay types. underlying information that goes into producing the Third, the data selected to be integrated into number, ToxPi provides a transparent visualization one slice are transformed into a slice score for each of both the rankings and the individual compound's compound (Figure C-2)
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From page 248...
... For the slices where information other evident that HPTE is more potent in ER assays than than quantitative "potency" is to be integrated, the is 2,4-D; this is shown visually by the HPTE slice that same procedure may be followed, with particular is extending farther from the origin than the slice for chemical property values, pathway scores, or other 2,4-D. The rankings can be used to compare categorical values used to provide a notion of the chemical toxicity or assess the similarity of predicted "activity" of each compound relative to other compound activity.
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From page 249...
... allows for applying Examples of weighting factors frequently applied are: weight factors to each slice, which introduces an  Weighting of end points within a domain (e.g., additional coefficient to the calculation of the overall carcinogenicity weighted heavier than ToxPi score for each compound. This information is respiratory effects within the human health easy to convey through ToxPi graphs, which will domain)
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From page 250...
... If possibility that confidence intervals generated using multiple data columns were integrated into a slice, the approach described here may be unreliable in the numerical values within each slice are sampled the following situations: if the measurements within with replacement, and these resampled values are each slice are on dramatically different scales (while used to calculate a bootstrap ToxPi statistic. The different scales can be combined within ToxPi, bootstrap ToxPi statistic is calculated exactly as the individual slices are best used to represent original statistic, but on the resampled data.
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From page 251...
... B: Confidence intervals in overall ToxPi score and relative rank of each compound.
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From page 252...
... visualization tool for transparent integration Dix, and R.J. Kavlock.
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Key Terms

  • confidence intervals
  • confidence interval
  • overall toxpi
  • relative rank
  • data integration

  • toxpi software
  • toxpi scores
  • numerical values
  • differential weighting
  • assay values

  • bootstrap toxpi
  • types available
  • weighted heavier
  • toxpi statistic
  • dot plot

  • data type
  • information types
  • effects weighted
  • multiple data
  • vitro assay

  • health perspectives
  • individual slices
  • assay data
  • relative chemical
  • data column

  • shown visually
  • compared extend
  • score components
  • data matrix
  • red asterisk


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