A Framework to Guide Selection of Chemical Alternatives (2014) / Chapter Skim
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6 Comparative Exposure Assessment
6 Comparative Exposure Assessment
Pages 69-80
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From page 69... ...
Some frameworks (e.g., employed in other alternatives assessment TURI 2006a) include exposure potential frameworks.
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From page 70... ...
70 A Framework to Guide Selection of Chemical Alternatives FIGURE 6-1 Committee's framework highlighting comparative exposure assessment (Step 6.3)
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From page 71... ...
that influence their toxicity and exposure. The presence of different functional groups and For the required elements of Step 6.3, the exposure physicochemical properties may increase (or considerations are limited to the stage at which the chemical is used for human exposures and the use and decrease)
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From page 72... ...
72 A Framework to Guide Selection of Chemical Alternatives FIGURE 6-2 An approach to comparative exposure assessment within the committee's chemical alternatives assessment framework. Exposure potential could be derived from either the outputs of simple exposure models or the comparison of key physicochemical properties to arrive at one of three determinations with respect to an alternative, as compared to a chemical of concern.
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From page 73... ...
and information on use and chemical and material physicochemical properties provides important properties can be used as a way to estimate the information in Step 2b. relative exposure potential of alternatives.32 Each of A comparative exposure assessment (Step 6.3, described in this chapter)
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From page 74... ...
Estimate relative exposure for each relative amount of exposure to both humans and scenario and route and predict partitioning into ecological receptors from the alternatives may partly environmental compartments: Depending on the depend on the amount of the chemical required to results from the simplified exposure models, the achieve the functional requirements identified in Step relative human exposure (taking into account the 2 (Chapter 4)
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From page 75... ...
Consider magnitude of change in key exposure models, can be illustrated with an air physicochemical properties: Comparing freshener comparison. As shown on Table 6-1, physicochemical properties that relate to ecological Fragrance A is used in an air freshener.
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From page 76... ...
Categorize relative exposure potential of uncertainties in hazard or exposure potential. alternatives: The inference of exposure potential If any alternatives are preferable because of could be derived from either the outputs of simple their inherent properties, that should be exposure models or the comparison of key noted for further consideration in Steps 7 and physicochemical properties to arrive at one of three 10 of the overall framework (Chapter 9)
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From page 77... ...
If the extent, pattern, and patterns and exposure pathways to further examine degree of exposure are considered to be how exposure might change. substantially equivalent between an alternative and the chemical of concern, then the determination of Quantitative comparative exposure assessment "safer" can be limited to the relative hazard of the is not considered a simple task.
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From page 78... ...
by substances to people and the environment. FHX Trent University Holistic fate and exposure model for chemical exposure (Farfield Human Exposure)
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From page 79... ...
risk assessments of chemicals used in consumer products, mainly laundry, cleaning, and personal care products. SHEDS US-EPA A probabilistic human exposure model.
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