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National Halothane Study: a Study of the Possible Association Between Halothane Anesthesia and Postoperative Hepatic Necrosis; Report. Edited by John P. Bunker [and Others] (1969) / Chapter Skim
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'THE TOXICOLOGY OF DICHLOROHEXAFLUOROBUTENE, by Ellis N. Cohen'
Pages 411-416

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
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From page 411...
... Studies of toxicity in animals cannot be directly extrapolated to man. The retrospective study reported herein was not designed to compare the effects of butene-contaminated and butene-free halothane, and a prospective study involving administration of such a potentially toxic material (butene-contaminated halothane)
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From page 412...
... - I20- Dctec- Flame CFjCHBrCI 1000 900 800 TOO 600 500 300 200 100 90 Observed short-lived rray spectra NoF standard 1.0 Energy (Mev) Flgure 3. -- Gamma ray spectrum obtained by Irradiation of NaF standard and liver tissue in area of low neutron flux.
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From page 413...
... Although DCHFB produces hepatic damage in some animals, a direct causeand-effect relationship between DCHFB and halothane hepatic necrosis in man remains unproved. Despite some species variations in toxicology, the presence of butene in halothane, even in trace amounts, represented a potential danger during the clinical administration of this anesthetic agent, and the manufacturer has properly eliminated it.
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From page 414...
... Note rapidly rising concentration of DCHFB in exhaled alveolar gas. o loo a 80 u o b"60 £20 -Constant iospired Hatothaoc tl.X)
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Key Terms

  • stock halothane
  • halothane study
  • inhaled concentration
  • national halothane
  • hepatic damage

  • central lobular
  • toxic effects
  • pathologic changes
  • anesthetic vaporizers
  • falling concentration

  • animal species
  • lobular necrosis
  • five patients
  • gas chromatography
  • butene concentration

  • blood solubility
  • rising concentration
  • hepatic clearance
  • little medical
  • species fatty

  • lower blood
  • ultraviolet meter
  • anesthetic agent
  • workers described
  • prospective study

  • exhaled alveolar
  • inhalation species
  • clinical administration
  • surgically removed
  • eight anesthetic


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