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Advances in Understanding Genetic Changes in Cancer Impact on Diagnosis and Treatment Decisions in the 1990s (1992) / Chapter Skim
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5. Summary and Specific Recommendations
Pages 65-68

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From page 65...
... Continuine medical education of physicians and incorporation of recent developments in understanding the genetic mechanisms of neoplasia into medical school curricula are essential if physicians are to acquire the necessary information. In addition to the education of clinicians, several other potential stumbling blocks must be overcome before genetic analysis can be considered a routine part of caring for the patient with cancer.
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From page 66...
... In cases where lymphoma is suspected, the clinician should provide the pathologist with sufficient fresh, unfixed tissue to allow for routine histology, immunohistochemistry, and gene rearrangement studies. Many of the most useful immunohistochemical stains, including those for immunoglobulin light chain, work well only on snap-frozen tissue, and it is therefore critical that residents and staff pathologists know how to freeze tissue in a way that minimizes ice crystal artifact and preserves morphology.
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From page 67...
... The Molecular Diagnostic Laboratory Cytogenetic analysis is typically performed in an established laboratory under various guidelines, such as those of New York State, and commonly run by a director certified by the American Board of Medical Genetics. In contrast, specific molecular diagnostic tests are being performed largely in individual research laboratories at large academic centers.
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From page 68...
... The procurement service established by the National Institutes of Health, which is designed to provide specimens to appropriate researchers, should aid this purpose, and this activity should be expanded, optimally with some standardized procedures for tumor characterization and clinical follow-up. Single reference laboratories employing well-controlled and reproducible methods in multiinstitutional studies should be utilized to increase the probability of finding significant associations.
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Key Terms

  • genetic analysis
  • molecular diagnostic
  • rearrangement studies
  • academic centers
  • diagnostic tests

  • medical genetics
  • support staff
  • cytogenetic analysis
  • american board
  • molecular lesions

  • diagnostic laboratory
  • gene rearrangement
  • solid tumors
  • molecular diagnosis
  • diagnostic laboratories

  • clinical pathology
  • contain acquired
  • increasing impact
  • immunoglobulin light
  • isolated community

  • invaluable resource
  • immunohistochemical stains
  • simplify detection
  • buffered saline
  • six hours

  • precise diagnosis
  • acquire mdl
  • commonly run
  • blue cell
  • cytogenetics laboratory


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