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Advances in Understanding Genetic Changes in Cancer Impact on Diagnosis and Treatment Decisions in the 1990s (1992) / Chapter Skim
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Supplementary Plates for Chapter 2
Pages 85-88

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 85...
... Closed circles represent red signals from c-H-abl (ABL probe) and open circles represent green signals from PEM12 (BCR probe)
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From page 86...
... PLATE 2 Leukemic cells from a patient with CLL hybridized with an oc-satellite probe for the centromere of chromosome 12. Both cells show three signals indicating trisomy 12.
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From page 87...
... After DNA was prepared from the tumors, six tumors representative of each clinical stage were grouped for electrophoresis, blotted, and hybridized with the pNB-1 probe for MYCN. The proportion with MYCN amplification was similar to the proportion in the total 89 tumors tested.
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From page 88...
... Southern blot analyses show the 12.5-kb ERBB2 band seen with Eco RI cut DNA. Northern blot analyses show the 4.5-kb ERBB2 transcript.
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Key Terms

  • circles represent
  • blot analyses
  • situ hybridization
  • green hybridization
  • cml patient

  • interphase hybridization
  • close proximity
  • protein band
  • signals resulting
  • northern blot

  • western blot
  • fusion gene
  • red signals
  • cml metaphase
  • hybridization signals

  • hybridization patterns
  • corresponding interphase
  • myelogeneous leukemia
  • normal chromosomes
  • six tumors

  • abl probe
  • represent green
  • closed circles
  • tumors representative
  • hybridization pattern

  • single red
  • clinical stage
  • interphase nuclei
  • represent red
  • cut dna


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