Multiple Chemical Sensitivities Addendum to Biologic Markers in Immunotoxicology (1992) / Chapter Skim
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Diagnostic Markers of Multiple Chemical Sensitivity
Diagnostic Markers of Multiple Chemical Sensitivity
Pages 117-138
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From page 117... ...
testing. When properly timed, certain immune function tests (TAT cells and chemical antibody levels)
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When this situation was corrected, both headaches and nose bleeds disappeared No other person in the office developed headaches and nose bleeds. The conclusion was reached that SM.
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62% were females, 38% were males. Their bloods were ermines and normal ranges were established for ad immune function tests reported In this paper.
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~ Whenever symptoms suggested impairment of neurological or psychological function, we suggested an electroencephalogram (EEG) and evoked response studies.
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OD analyses of TMA-HSA, and TMA-BSA were done to determine the on~nber of MA residues linked to the corresponding carrier protein. The concentration of the cattier protein was converted to molar concentration with the molecular weight of HSA and BSA.
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incubation for 4 hours at 20 C, followed by washing 4 times, (4) addition of 100 ~ of an Optimal dilution of alkaline phosphatase labeled affinity purified goat anti-human IgE: ( )
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This incomplete observation of inhibition of IN antibody was mainly related to nonavailabili~cy of serum with high IgE: titers aghast different chemicals In our laboratory Determination of Normal Levels of Antibodies (Controls) : Based on the above procedures, 160 blood donor samples of healthy individuals, of both sexes, between the ages of 22-55, were examined for antibody levels against P-HSA, TD-HSA, TMA-HSA, PA-HSA, and B-HSA.
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Also, the percentage of doubly stamed cells was determined. Estimates of absolute numbers of lymphocytes positive for the respective surface markers were determined by multiplying peripheral lymphocyte cell count by the percentage of positive cells for each surface marker.
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TABLE m F=mination of Nose, Sinuses and Pulmonary Function In Patients with Multiple Chemical Sensitivity TEST ENT Specialist Sinus x-rays PET Chest x-rays % ABNORMAL 100 52 62 16 of PA~=S 19 25 78 32 Table m shows that a thorough END exam wiD show abnormalities In a high
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From page 126... ...
TABLE IV . Immune Cell Population In Patients with Multiple Chemical Sensitivity TEST % ABNORMAL # OF Patients TA1 66 92 H/S 50 109 Helper 43 ~09 Lymphs 27 110 B-Celis 25 104 For normal ranges, see ted.
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Table vm illustrates a case In which chemical antibodies were a poor marker of chemical sensitive. By contrast, cells of the immune system were significantly abnormal and slowly approached normal as the patient stayed away from her home for several months.
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From page 128... ...
in a student with MCS who entered an anatomy laboratory for sit ent length of time to become severely symptomatic By contrast, T-cells and helpersuppressor ratios did not Mange main that .= e time mtenral. Table X illustrates increase in IgM antibodies to TMA, pithalic anhy~ide and compounds with a benzene ring, and also In IgG antibodies to the benzene nag, approximately two weeks after significant exposure.
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Not shown in table XVI are additional results with respect to auto~mmunity: ANA titers were positive in 17% of 96 patients. The highest percentage of elevated antibodies was seen when anti-myelin antibodies were studied.
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These chambers win however be needed for further research. Table XVII shows a list of chemicals brought to the senior author by a patient with MCS.
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Further studies are needed to dete~ne which of these compounds cause antibody formation. Our data surest that chemical exposure can push some patients in the direction of autoimmune &ease.
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C., 45, male, with MCS before and after exposure to Venomous" environment on 9-25-90. While we have come to elect a high percentage of abnormal immune function tests, we were surprised at the high percentage of abnormal neurological tests.
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to gasoline fumes. TABLE XIV WIFE HUSBAND NORMAL RANGE IgG / I¢M IgG / I¢M IgG / I¢M FO 6,400 / 3,200 6,400 / 1,600 1,600 / 6,400 ISO 12,800 /1,600 6,400 /1,600 1,600 / 6,400 TMA 6,400 / 1,600 6,400 / 1,600 1,600 / 6,400 PHI HA 1,600 / 3,200 1,600 / 1,600 1,600 / 6,400 M~ed couple (male, 38 amd female, 34)
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It should be understood that not all seven systems (central nervous system, peripheral nervous system, nose and sinuses, PET, T-cells subsets, chemical antibodies, autoimmune paved are always affected. However, we suggest that abnormalities in four out of these seven systems strengthen He suspicion of MCS.
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From page 135... ...
1 cutting fluid Industrial lacquer Chevron thinner 135 The suggestion to use four out of seven criteria is taken from the diagnostic criteria for systemic lupus e~hematosus (SLE) , where four out of eleven criteria have to be present to make the diagnosis (see table xVm)
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Whenever possible, longitudinal studies should be performed In which the patient is used as his/her own control. Increases In TA1 cells and chemical antibodies can then be seen following self-reported umutentional exposure and are therefore suggested as markers of MCS.
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1972. Large scale preparation of myelin basic protein Dom central nervous tissue of several mamalian species, Prep.
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138 DIAGNOSTIC MARKERS In humans Title long-term inhalation exposure to formaldehyde.
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