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Multiple Chemical Sensitivities Addendum to Biologic Markers in Immunotoxicology (1992) / Chapter Skim
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Developing Clinical Research Protocols for Studying Chemical Sensitivities
Pages 151-154

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From page 151...
... In addition, some data is now available on both endogenous and added low molecular weight organic chemicals ~ food and water. Claims of adverse health effects from these exposures are far-rang~ng, and the challenge is now upon the clinical investigator to sc~entificaBy dete~e if there are adverse health effects associated with these exposures.
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From page 152...
... Common features of these diseases are a wa~g and waning course, localized tissue infl=nmation, and ultimately tissue destruction. They are candidates for Stage 2 and Stage 3 illnesses of the Hypothetical Chemical Stress Syndrome, discussed elsewhere in these proceeding TABLE 1 Some of the Diseases Whose Relationship to En~ro~ental Chemicals Needs Clarification Asthma Auto~mmune hemol~c anemia Crohn's Disease Depression Manic depressive illness Multiple sclerosis Rheumatoid Arthritis Schizophrenia Systemic Lupus Ery~ematosus Ulcerative Coitus Clinical research protocols must be designed to incorporate suitable control Soups.
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From page 153...
... In the ong~nal clinical Ascription of the multiple chemical sensitivity syndrome, it was claimed that chemically sensitive patients chronically exposed to chemical inhalants do not react acutely to chemical challenges and go through a withdrawal phase lasting approximately five days when removed Tom the chemical environment. Chromc symptoms are said to resolute after withdrawal, but the patients develop acute symptoms when rechaBenged with chemicals Clinical studies must allow for this adaptation mechanism in order to be accepted.
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Key Terms

  • multiple chemical
  • disease activity
  • volatile organic
  • chemical sensitivity
  • research protocols

  • sensitivity syndrome
  • clinical studies
  • dose chemical
  • chemical environment
  • patient populations

  • research units
  • indoor air
  • chemical exposures
  • suitable control
  • anecdotal data

  • multiple chemicals
  • level exposures
  • weight organic
  • chemical considered
  • clinical investigator

  • low molecular
  • chronically exposed
  • defined questions
  • occupational exposure
  • tissue destruction

  • polysomatic complaints
  • volunteers exposed
  • original description
  • symptoms including
  • patients enter


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