Multiple Chemical Sensitivities Addendum to Biologic Markers in Immunotoxicology (1992) / Chapter Skim
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Case Definitions for Multiple Chemical Sensitivity
Case Definitions for Multiple Chemical Sensitivity
Pages 41-46
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From page 41... ...
is an acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses far below those established ~ the general population to cause harmful effects. No single widely accepted test of physiologic function can be shown to correlate with symptoms.
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From page 42... ...
The petro-chemical problem 42 CASE DEFINITIONS FOR MULTIPLE CHEMICAL SENSlTIVIIY TABLE 1 Cause Mechanism Effect Env~ronmentallym~uced Immunolog~cillness Multiple chemical illness sensitivities (MCS) Immunotoxici~ Immune dysfunction Immune dysregulation Conditioned odor response Fear/anxiety Mass psychogenic illness Vanous psychiatric disorders Multiple chemical sensitivity syndrome Chemical hypersensitivity syndrome Universal allergy 20th-centu~y illness Total allergy syndrome En~omnental allergy or ess Cerebral allergy Environmental maladaptation syndrome Food and chemical sensitivity This case definition, intended for epidemiological use, is iIItentionally ~TOW.
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From page 43... ...
that allegedly can result in a seemingly endless array of physical and mental syndromes "d He Sequent absence of findings on routme physical examination, the practitioner who sees these patients with their divergent and unfamiliar lily of complaints is at great disadvantage ~ trying to diagnose the condition. To circumvent this problem, we propose the following operational definition of multiple chemical sensitivity for diagnostic purposes, a definition that is based upon environmental testing: The patient with multiple chemical sensitivities can be discovered by removal from the suspected offending agents anal try rechallenge, after an appropriate interval, under strictly controlled environmental conditions.
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From page 44... ...
Whatever case definitions emerge for diagnostic or research purposes, decisions concem~g Safe levels of chemical exposure for regulatory standard-se~g, criteria of eligibility for disability awards under workers' compensation or social second, and criteria of eligibility for alternative employment or housing ultimately need to be based on suitable definitions. These definitions should be expected to differ in exactness and stnugency, and may be in flux until more research results are obtained.
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From page 45... ...
(ad.) Workers with Multiple Chemical Sensitivities, Occupational Medicine: State of the Art Reviews (1987b)
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