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Issues in Risk Assessment (1993) / Chapter Skim
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1. INTRODUCTION
Pages 111-112

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From page 111...
... Soms4,5 & M Szyszkowicz1 Current practice in carcinogen bioassay calls for exposure of experimental animals at doses up to the maximum tolerated dose (MTD)
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From page 112...
... . High doses such as the MTD are used to enhance tumor response rates, thereby increasing the likelihood of observing elevated tumor occurrence rates in a small sample of experimental animals.
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Key Terms

  • animal cancer
  • cancer tests
  • maximum tolerated
  • tolerated dose
  • carcinogen bioassay

  • bioassay calls
  • observing elevated
  • response rates
  • studies conducted
  • print version

  • appreciably altering
  • carcinogenic effects
  • risk factors
  • unit risk
  • effects detected

  • enhance tumor
  • highly correlated
  • altering body
  • cancer risk
  • maximum dose

  • body weight
  • elevated tumor
  • tumor occurrence
  • occurrence rates
  • dose risks

  • tumor response
  • predicting low
  • quantitative measures
  • low dose
  • thereby increasing


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