Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression Workshop Summary (2015) / Chapter Skim
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6 Lessons Learned from the Schizophrenia Field
6 Lessons Learned from the Schizophrenia Field
Pages 49-54
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From page 49... ...
. • Several workshop participants identified concerns about developing a composite cognitive battery for cognition in depression similar to that developed through a consensus process for schizophrenia (Fava, Keefe, Sahakian)
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While the steps undertaken by MATRICS to address these challenges may offer lessons for the depression field, some workshop participants expressed concerns about strictly following the MATRICS model. For example, the initiative developed a consensus cognitive battery (the MCCB)
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In developing this tool, MATRICS employed a multistep process (see Figure 6-1) , which began by identifying the relevant cognitive domains to be tested, selecting the criteria for appropriate tests of those domains, soliciting nominations for tests, narrowing the number of tests to six or fewer per domain, creating a database and evaluating the tests using the criteria defined earlier, selecting two to five tests per domain for the "beta" battery, conducting a psychometric study with this battery, finalizing the battery, and then co-norming the tests of a community sample.
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The nneed for a co-primary meaasure inn schizophren nia trials ledd to the lauunch of anoother initiativve, MATR RICS-CT. Workshop W partiicipants discu ussed whetherr the field shhould apply tthe MATR RICS approacch to building g an assessmeent tool to meeasure cognitiive impairrment in depreession.
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She emphasized it was essential to not stifle progress in the field. Richard Keefe suggested that for depression clinical trials, the focus should be more on cognitive neuroscience processes or practicality for use in trials, yet he noted that none of the elegant and exquisite neuropsychological tests derived from the CNTRICS program have yet been used in a Phase II clinical trial.
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54 COGNITIVE DYSFUNCTION IN DEPRESSION noted that multisite clinical trials pose additional challenges in terms of detecting a signal.
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