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Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression Workshop Summary (2015) / Chapter Skim
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2 The Burden of Cognitive Dysfunction in Depression
Pages 9-14

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From page 9...
... However, there is now increased recognition that cognitive dysfunction in depression occurs as both cognitive biases, such as distorted information processing and increased attention to negative stimuli, and cognitive deficits, such as impairments in attention, short-term memory, and executive functioning (Murrough et al., 2011)
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From page 10...
... . For example, in a study of 48 patients hospitalized with a diagnosis of MDD, nearly 60 percent remained functionally disabled 6 months after hospitalization despite significant improvement in depressive symptoms (Jaeger et al., 2006)
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From page 11...
... Modulating these circuits are neurotransmitters such as dopamine, noradrenaline, and serotonin, said Sahakian. One phenomenon observed in patients with MDD, as well as in those with subclinical depression and even healthy controls with genetic variants linked to an increased risk for depression, is the tendency to have "catastrophic reactions to errors," said Diego Pizzagalli, professor of psychiatry at Harvard Medical School (Elliott et al., 1997; Holmes and Pizzagalli, 2008a; Holmes et al., 2010; Pizzagalli et al., 2006)
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From page 12...
... . Preseented by Barbaara Sahakian at the IOM M Workshop on Enabling Discovery, Deevelopment, aand Translaation of Treatm ments for Cog gnitive Dysfunnction in Deprression, Februaary 24, 20115.
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From page 13...
... . DEFINING COGNITIVE IMPAIRMENT IN DEPRESSION Given the importance of cognitive impairment in depression, several workshop participants called for an expansion of the diagnostic criteria for MDD in the DSM-5, particularly to include symptoms that capture hot cognition, which is important in depression.
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Key Terms

  • hot cognition
  • cognitive impairment
  • depressed patients
  • cold cognitive
  • cognitive biases

  • cognitive deficits
  • information processing
  • depression occurs
  • diagnostic criteria
  • cognitive neuroscience

  • cognitive impairments
  • cognitive issue
  • cognitive processes
  • cognitive flexibility
  • cognitive loop

  • defining cognitive
  • nonverbal approaches
  • prefrontal cortex
  • tients hospitalized
  • functionally disabled

  • criteria currently
  • reduced productivity
  • participants called
  • persisting deficits
  • depression lacks

  • garrett alexander
  • business plan
  • negatively biased
  • distorted information
  • region responsible


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