Reproducibility Issues in Research with Animals and Animal Models Workshop in Brief (2015) / Chapter Skim
Currently Skimming:
Reproducibility Issues in Research with Animals and Animal Models
Reproducibility Issues in Research with Animals and Animal Models
Pages 1-8
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 1... ...
At this workshop1, researchers from around (an ILAR Roundtable series) the world explored the many facets of animal-based research that could contribute to irreproducible results, including perspectives on improving experimental planning, design, and execution; the importance of reporting all methodological details; and efforts to establish harmonization principles of reporting on the care and use of animals in research studies.
|
From page 2... ...
argued that reproducibility can be results that are characterized by funding divided into empirical, statistical and computational agencies as innovative and pointed to the 2003 National Research Council • Researchers face few negative consequences report Sharing Publication-Related Data and Materials, for publishing flawed or incorrect results, or whose first principle is that "authors should include in for making exaggerated claims4 their publications the data, algorithms, or other infor mation that is central or integral to the publication PROBLEMS WITH STUDY DESIGN - that is, whatever is necessary to support the major According to Ioannidis, flawed study design claims of the paper and would enable one skilled significantly contributes to irreproducible results: in the art to verify or replicate the claims." Stodden • Poor protocols and documentation urged that all computational procedures be included • Poor utility of information in publications. • Statistical power and outcome misconceptions STUDY DESIGN, REPRODUCIBILITY AND • Lack of consideration of other (usually prior)
|
From page 3... ...
on the response variable -- can make experiments both more comprehensive and more efficient", thus REPRODUCIBILITY ISSUES AND PUBLIC producing added knowledge and a higher degree of TRUST IN SCIENCE precision with the same numbers of observation. Robert Bazell, a former journalist now at Yale Festing's list of methodological issues that University, observed that the public was not yet aware lead to false positive results includes: of or concerned with reproducibility issues.
|
From page 4... ...
Zebrafish Monte Westerfield (University of Oregon) HARMONIZATION OF PRINCIPLES OF explained the unique advantages of zebrafish as a ANIMAL CARE, USE AND REPORTING model system to investigate certain human biology Coenraad Hendriksen discussed a 2009 ILAR and disease phenotypes, which have led to a dramatic workshop, which he chaired, on the challenges of increase of the number of NIH grants that fund conducting animal research globally.
|
From page 5... ...
He argued that accurate assessStudies13, intended primarily for editors of scientific ment of this relationship is critical: as sentient beings, journals. Everett argued that, because reporting of animals experience suffering, therefore their sacrifice methodological information relating to laboratory should be for a greater benefit to mankind; preclinical animal care and use differs based on the field of study, research establishes the rationale and justification to the journal, and the type of study, journal editors expose patients to unproven and potentially harmful could customize their needs but should publish their drugs; animal research directly informs healthcare journal's expectations; issue guidance to editors, practices, as physicians often rely on information from authors and reviewers; and articulate clear policies on preclinical studies to treat idiosyncratic conditions.
|
From page 6... ...
He further argued Kathryn Bayne (AAALAC International) that IACUC functions contribute to enhanced repro- pointed to the recent National Science Board ducibility by ensuring humane handling, care and recommendation to "develop standard operating treatment of research animals and that the committee procedures and a single set of guidelines that can should evaluate scientific aspects of research protocols be cited in IACUC protocols"20, but many workshop affecting the welfare and use of laboratory animals, speakers and participants expressed concerns including hypothesis testing, sample size determina- about additional regulatory burden by funding tion, and adequacy of controls.
|
From page 7... ...
Bringing scientists, instituthe odds of a research outcome being true diminish tional representatives, research veterinarians, journal in the presence of bias, small effect size or small editors, funders, and members of the public together studies; in "hot" fields with significant competition will allow discussions in areas of broad agreement and among research teams; when results are highly antici- divergence, and help strengthen the commitment of pated; when datasets are not targeted; and when the scientific community to uphold and enact prinstatistical analyses are more flexible. In the world of ciples of reproducibility in research involving animals.
|
From page 8... ...
The review was coordinated by Janet Garber, Private Consultant, and the comments and draft manuscript remain confidential to protect the integrity of the process. Statement of Task An ad hoc committee will organize and conduct a public workshop to discuss fundamental aspects of experimental design of research using animals and animal models, aimed at improving reproducibility.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.