Health Effects of Ingested Fluoride (1993) / Chapter Skim
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4 REPRODUCTIVE EFFECTS OF FLUORIDE
4 REPRODUCTIVE EFFECTS OF FLUORIDE
Pages 73-84
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From page 73... ...
Women exposed occupationally to air heavily laden with superphosphates demonstrated increases in menstrual irregularities and genital irritations when compared with unexposed controls (Kuznetzova, 1969~. However, occupational exposure to many other compounds in the cryolite and superphosphate industries makes it difficult to implicate any one substance, such as fluoride, in inducing these health effects.
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From page 74... ...
Most "natural ingredient" rodent diets containing bone meal that are available today, however, have fluoride concentrations ranging from 10 to 50 mg/kg. The bioavailability of fluoride from these diets is 45-50% (Whitford, 1991~.
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From page 75... ...
fluoride deficiency from developing, apparently by increasing the absorption of iron and copper, both of which were present in marginal concentrations in Messer's mouse diet. Studies of reproduction in cattle have generally shown no effect of fluoricleunIess intake is suff~cientto produce skeletal fluorosis and other adverse effects.
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From page 76... ...
76 Cal .t ¢ 4 ~: .c .e o a V]
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From page 78... ...
The authors concluded that no differences existed among the groups in growth rate or reproductive performance, although "the conception rate for the entire experiment was low." Milk production was "somewhat less" in animals receiving I.5 mg/kg per day each year, "but as small numbers of animals were involved, the observations are inconclusive." In their study, van Rensburg and de Vos (1966) noted the effects of fluoride on reproductive performance of Afrikaner heifers receiving fluoride at 5-12 mg/L of drinking water.
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From page 79... ...
The fluoride concentrations in bone ash ranged from 300 ppm in a 2-year-old cow to 2,100 ppm in a 6-year-old cow. Considering the adverse effects that were recorded and the reportedly high concentrations of fluoride in the diet, those values were very low.
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From page 80... ...
Femur fluoride concentrations of the kestrels were proportional to fluoride intake. The clutch sizes tended to be smaller as the concentration of fluoride intake increased, but the differences were not statistically significant.
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From page 81... ...
The fluoride concentrations of new diets used from 1985 to 19X7 ranged from ~ to 23 mg/kg. Bone fluoride concentrations declined, kit production increased anti kit ~'rviv~hilitv ~nnrn~rh~A normal expectations.
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From page 82... ...
of reproductive problems in dogs in this kennel." DISCUSSION Adverse effects on reproductive performance associated with high concentrations of fluoride intake have been demonstrated in mice, rats, cattle, owls, hens, kestrels, dogs, mink, and foxes (reducer] lactation)
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From page 83... ...
of the dosage scale. It is recommended that future studies of reproductive effects of fluoride intake include control diets with fluoride concentrations of less than I.0 mg/kg.
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